Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site (Q27749281)

2

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A J Oakley

3

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D Verger

4

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J Flanagan

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G Chelvanayagam

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K L Tan

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P G Board

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M W Parker

Glutathione S-transferases: reaction mechanism, structure, and function

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language of work or name

English

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publication date

15 March 1998

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published in

Structure

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volume

6

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issue

3

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page(s)

309-22

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cites work

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Glutathione transferases--structure and catalytic activity

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Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties

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Theta, a new class of glutathione transferases purified from rat and man

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Characterization of rat spleen prostaglandin H D-isomerase as a sigma-class GSH transferase

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Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue

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X-ray crystal structures of cytosolic glutathione S-transferases. Implications for protein architecture, substrate recognition and catalytic function

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Structure and function of glutathione S-transferases.

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Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1

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Evidence for an essential serine residue in the active site of the Theta class glutathione transferases

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The reaction of aralkyl sulphate esters with glutathione catalysed by rat liver preparations

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Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate

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Novel theta class glutathione S-transferases Yrs-Yrs' and Yrs'-Yrs' in rat liver cytosol: their potent activity toward 5-sulfoxymethylchrysene, a reactive metabolite of the carcinogen 5-hydroxymethylchrysene

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Isolation of a mouse theta glutathione S-transferase active with methylene chloride

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Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

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Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22

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Purification and characterization of a recombinant human Theta-class glutathione transferase (GSTT2-2).

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Crystal structure of a theta-class glutathione transferase.

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Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2 A resolution: structural characterization of herbicide-conjugating plant glutathione S-transferases and a novel active site architecture

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Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: catalysis with different substrates involves different residues

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Thioredoxin--a fold for all reasons

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Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes

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The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution

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Three-dimensional structure, catalytic properties, and evolution of a sigma class glutathione transferase from squid, a progenitor of the lens S-crystallins of cephalopods

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Three-dimensional structure of class π glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8 Å resolution

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Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate

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A structurally derived consensus pattern for theta class glutathione transferases

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Access of ligands to cavities within the core of a protein is rapid

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Structure of a human lysosomal sulfatase

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Sulphate sequestered in the sulphate-binding protein of Salmonella typhimurium is bound solely by hydrogen bonds

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The mechanism of the reaction between glutathione and 1-menaphthyl sulphate catalysed by a glutathione S-transferase from rat liver

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Sequence analysis and expression of the bacterial dichloromethane dehalogenase structural gene, a member of the glutathione S-transferase supergene family

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Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily

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Drosophila glutathione S-transferases have sequence homology to the stringent starvation protein of Escherichia coli

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A bacterial enzyme degrading the model lignin compound beta-etherase is a member of the glutathione-S-transferase superfamily.

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7 January 2021

Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.

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Solvent content of protein crystals

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7 January 2021

Where freedom is given, liberties are taken

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Homology model for the human GSTT2 Theta class glutathione transferase

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Improved Fourier coefficients for maps using phases from partial structures with errors

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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