The 2.8 A crystal structure of Gla-domainless activated protein C (Q27734660)

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31 October 2019

title

The 2.8 A crystal structure of Gla-domainless activated protein C (English)

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31 October 2019

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Mather T

1

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31 October 2019

Oganessyan V

2

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31 October 2019

Hof P

3

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Huber R

4

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Foundling S

5

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Esmon C

6

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Bode W

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language of work or name

English

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publication date

1 December 1996

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31 October 2019

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31 October 2019

volume

15

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issue

24

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31 October 2019

page(s)

6822-6831

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Structure of human des(1-45) factor Xa at 2.2 A resolution

31 October 2019

cites work

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Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

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X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B

20 March 2017

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The nucleotide sequence of the gene for human protein C

20 March 2017

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The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

20 March 2017

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

20 March 2017

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20 March 2017

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On the size of the active site in proteases. I. Papain

20 March 2017

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The mechanism of inactivation of human factor V and human factor Va by activated protein C

20 March 2017

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Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

20 March 2017

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Characterization of a cDNA coding for human protein C

20 March 2017

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The roles of protein C and thrombomodulin in the regulation of blood coagulation

20 March 2017

1 reference

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Database of homology-derived protein structures and the structural meaning of sequence alignment

20 March 2017

1 reference

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Activation of purified prothrombin to autoprothrombin I or autoprothrombin II (platelet cofactor II or autoprothrombin II-A).

7 April 2017

1 reference

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Interactions and inhibition of blood coagulation factor Va involving residues 311-325 of activated protein C.

29 September 2017

1 reference

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Mutation in blood coagulation factor V associated with resistance to activated protein C.

29 September 2017

1 reference

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Mutation of Glu-80-->Lys results in a protein C mutant that no longer requires Ca2 for rapid activation by the thrombin-thrombomodulin complex.

29 September 2017

1 reference

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Alteration of the substrate and inhibitor specificities of blood coagulation factor VIIa: importance of amino acid residue K192.

29 September 2017

1 reference

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Thrombophilia: the discovery of activated protein C resistance

29 September 2017

1 reference

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Kinetics of the heparin-enhanced antithrombin III/thrombin reaction. Evidence for a template model for the mechanism of action of heparin.

29 September 2017

1 reference

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Generation of fibrinolytic activity by infusion of activated protein C into dogs

29 September 2017

1 reference

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Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C

29 September 2017

1 reference

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Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity

29 September 2017

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Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies

29 September 2017

1 reference

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Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif

29 September 2017

1 reference

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Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin

29 September 2017

1 reference

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Natural protein proteinase inhibitors and their interaction with proteinases

29 September 2017

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A comparison of three heparin-binding serine proteinase inhibitors

29 September 2017

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A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization

29 September 2017

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The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0

29 September 2017

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29 September 2017

Protein C activation.

1 reference

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Interaction of activated protein C with serpins

2 June 2018

1 reference

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Resistance to inhibition by alpha-1-anti-trypsin and species specificity of a chimeric human/bovine protein C.

2 June 2018

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A comparative study of partial primary structures of the catalytic region of mammalian protein C.

2 June 2018

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The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin

2 June 2018

1 reference

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Specificity of activated human protein C.

2 June 2018

1 reference

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Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452507

Identification of a sequence of human activated protein C (residues 390-404) essential for its anticoagulant activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452507

Identification of divalent metal ion-dependent inhibition of activated protein C by alpha 2-macroglobulin and alpha 2-antiplasmin in blood and comparisons to inhibition of factor Xa, thrombin, and plasmin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452507

A novel exosite in the light chain of human activated protein C essential for interaction with blood coagulation factor Va.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452507

Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=452507

Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide

27 November 2018

1 reference

12 December 2020

Treatment of purpura fulminans in meningococcemia with protein C concentrate

1 reference

12 December 2020

Contribution of Residue 192 in Factor Xa to Enzyme Specificity and Function

1 reference

12 December 2020

Tryptophans 231 and 234 in protein C report the Ca(2 )-dependent conformational change required for activation by the thrombin-thrombomodulin complex

1 reference

12 December 2020

Protein C deficiency: a database of mutations, 1995 update. On behalf of the Subcommittee on Plasma Coagulation Inhibitors of the Scientific and Standardization Committee of the ISTH

1 reference

12 December 2020

Relationship of "new" vitamin K-dependent Protein C and "old" autoprothrombin II-a

1 reference

12 December 2020

Amino acid sequence of the light chain of bovine protein C

1 reference

12 December 2020

Amino acid sequence of the heavy chain of bovine protein C.

1 reference

12 December 2020

Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C

1 reference

12 December 2020

Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity

1 reference

12 December 2020

Activation of protein C and its distribution between its inhibitors, protein C inhibitor, alpha 1-antitrypsin and alpha 2-macroglobulin, in patients with disseminated intravascular coagulation

1 reference

12 December 2020

Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors

1 reference

12 December 2020

10.1002/J.1460-2075.1996.TB01073.X

Identifiers

DOI

1 reference

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31 October 2019

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31 October 2019

PubMed publication ID

9003757

1 reference