Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies (Q27701444)

7

Darren C Tomlinson

0 references

Andrew J. Wilson

10

Andrew J Wilson

0 references

Stuart L. Warriner

8

Stuart L Warriner

0 references

Thomas A Edwards

11

Thomas A Edwards

0 references

Christian Tiede

Christian Tiede

6

0 references

George M. Burslem

George M Burslem

4

0 references

Alexander L Breeze

Alexander L Breeze

5

0 references

author name string

Hannah F Kyle

1

0 references

Kate F Wickson

2

0 references

Jonathan Stott

full work available at URL

3

0 references

language of work or name

1 reference

October 2015

0 references

http://eprints.whiterose.ac.uk/87483/

content deliverer

White Rose Research Online

0 references

published in

Molecular BioSystems

0 references

volume

11

0 references

issue

10

0 references

page(s)

2738-49

0 references

cites work

Hallmarks of Cancer: The Next Generation

1 reference

Biological consequences of tumor hypoxia

21 January 2018

1 reference

Targeting tumour angiogenesis with small molecule inhibitors of hypoxia inducible factor

21 January 2018

1 reference

CREB-binding protein and p300 in transcriptional regulation

21 January 2018

1 reference

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

21 January 2018

1 reference

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

21 January 2018

1 reference

Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

21 January 2018

1 reference

Fine-tuning multiprotein complexes using small molecules

21 January 2018

1 reference

Principles of protein-protein interactions

21 January 2018

1 reference

The atomic structure of protein-protein recognition sites

21 January 2018

1 reference

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

Anatomy of hot spots in protein interfaces

21 January 2018

1 reference

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

Hot spot-based design of small-molecule inhibitors for protein-protein interactions.

21 January 2018

1 reference

Development of HIF-1 inhibitors for cancer therapy

21 January 2018

1 reference

A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth

21 January 2018

1 reference

Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications

21 January 2018

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

21 January 2018

1 reference

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

21 January 2018

1 reference

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

1 reference

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

21 January 2018

1 reference

Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer.

21 January 2018

1 reference

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

21 January 2018

1 reference

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

1 reference

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

21 January 2018

1 reference

Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway

21 January 2018

1 reference

Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.

21 January 2018

1 reference

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix

21 January 2018

1 reference

Small-molecule proteomimetic inhibitors of the HIF-1α-p300 protein-protein interaction

21 January 2018

1 reference

Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling.

21 January 2018

1 reference

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

21 January 2018

1 reference

Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex.

21 January 2018

1 reference

Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP.

21 January 2018

1 reference

Binding Model for the Interaction of Anticancer Arylsulfonamides with the p300 Transcription Cofactor.

21 January 2018

1 reference

Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

1 reference

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein

21 January 2018

1 reference

Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

21 January 2018

1 reference

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha

21 January 2018

1 reference

Phage display in pharmaceutical biotechnology

21 January 2018

1 reference

Searching for Peptide Ligands with an Epitope Library

21 January 2018

1 reference

Peptides on phage: a vast library of peptides for identifying ligands

21 January 2018

1 reference

Random peptide libraries: a source of specific protein binding molecules

21 January 2018

1 reference

Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications

21 January 2018

1 reference

Structure-function studies of an engineered scaffold protein derived from stefin A. I: Development of the SQM variant.

21 January 2018

1 reference

Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant

21 January 2018

1 reference

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

21 January 2018

1 reference

Helix-mediated protein--protein interactions as targets for intervention using foldamers

21 January 2018

1 reference

Assessing Helical Protein Interfaces for Inhibitor Design

21 January 2018

1 reference

Efficient N-terminal labeling of proteins by use of sortase.

21 January 2018

1 reference

Deep sequencing analysis of phage libraries using Illumina platform

21 January 2018

1 reference

Elucidating the folding problem of helical peptides using empirical parameters

21 January 2018

1 reference

Phage display screening without repetitious selection rounds

21 January 2018

1 reference

Peptide Phage Display as a Tool for Drug Discovery: Targeting Membrane Receptors

21 January 2018

1 reference

CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding

21 January 2018

1 reference

Engineered protein scaffolds as next-generation antibody therapeutics.

21 January 2018

1 reference

Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands

21 January 2018

1 reference

Tendamistat as a scaffold for conformationally constrained phage peptide libraries

21 January 2018

1 reference

In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.

21 January 2018

1 reference

Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain

21 January 2018

1 reference

A conformationally homogeneous combinatorial peptide library.

21 January 2018

1 reference

New binding specificities derived from Min-23, a small cystine-stabilized peptidic scaffold

21 January 2018

1 reference

HADDOCK: a protein-protein docking approach based on biochemical or biophysical information

21 January 2018

1 reference

BALBES: a molecular-replacement pipeline

21 January 2018

1 reference

The Buccaneer software for automated model building. 1. Tracing protein chains

21 January 2018

1 reference

PHENIX: building new software for automated crystallographic structure determination

21 January 2018

1 reference

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/C5MB00284B

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

Altmetric DOI

10.1039/C5MB00284B

0 references

1025523864

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

26135796

1 reference

Consolidated OpenCitations Corpus – April 2017