Crystal structure of deglycosylated human IgG4-Fc (Q27684440)

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9 June 2020

author name string

Roy Jefferis

series ordinal

2

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9 June 2020

Brian J Sutton

series ordinal

3

1 reference

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9 June 2020

publication date

November 2014

0 references

published in

Molecular Immunology

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9 June 2020

volume

62

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9 June 2020

issue

1

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9 June 2020

page(s)

46-53

1 reference

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Immunoglobulin G1 Fc Domain Motions: Implications for Fc Engineering

9 June 2020

cites work

1 reference

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Structural Basis for Enhanced HIV-1 Neutralization by a Dimeric Immunoglobulin G Form of the Glycan-Recognizing Antibody 2G12

20 March 2017

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Structural Determinants of Unique Properties of Human IgG4-Fc

20 March 2017

1 reference

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High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation

20 March 2017

1 reference

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IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface

20 March 2017

1 reference

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Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange

20 March 2017

1 reference

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Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis

20 March 2017

1 reference

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Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

20 March 2017

1 reference

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Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

20 March 2017

1 reference

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Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

20 March 2017

1 reference

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Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose

20 March 2017

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Structure of the murine unglycosylated IgG1 Fc fragment

20 March 2017

1 reference

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Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions

20 March 2017

1 reference

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New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2·1-Å resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

The crystal structure of rabbit IgG-Fc

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

The structure of a human type III Fcgamma receptor in complex with Fc

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Convergent solutions to binding at a protein-protein interface

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution

20 March 2017

1 reference

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Overview of the CCP4 suite and current developments

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

1 reference

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20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

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How good are my data and what is the resolution?

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Complement is activated by IgG hexamers assembled at the cell surface

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Revisiting the role of glycosylation in the structure of human IgG Fc.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Isotype and glycoform selection for antibody therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Crystallographic model quality at a glance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Immunoglobulin G4: an odd antibody

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

C1q and its growing family.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

29 September 2017

IgG4 breaking the rules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

The immunoglobulin fold family: sequence analysis and 3D structure comparisons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Antibody: the flexible adaptor molecule

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

The binding affinity of human IgG for its high affinity Fc receptor is determined by multiple amino acids in the CH2 domain and is modulated by the hinge region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

The human c1q globular domain: structure and recognition of non-immune self ligands

29 September 2017

1 reference

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Chimeric human-simian anti-CD4 antibodies form crystalline high symmetry particles

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

A comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

The biological effects of IgM hexamer formation.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Atomic resolution model of the antibody Fc interaction with the complement C1q component

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Species-Specific Determinants in the IgG CH3 Domain Enable Fab-Arm Exchange by Affecting the Noncovalent CH3-CH3 Interaction Strength

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Mechanism of Immunoglobulin G4 Fab-arm Exchange

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4166458

Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry

27 November 2018

1 reference

12 December 2020

A comparative analysis of disease-associated changes in the galactosylation of serum IgG

1 reference

12 December 2020

Impact of Glycosylation on Effector Functions of Therapeutic IgG

1 reference

12 December 2020

Abnormal glycosylation of serum igg from patients with chronic inflammatory diseases

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12 December 2020

10.1016/J.MOLIMM.2014.05.015

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24956411 AND SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24956411 AND SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

24956411

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24956411 AND SRC:MED&resulttype=core&format=json