Structural basis for the drug extrusion mechanism by a MATE multidrug transporter (Q27684293)

14

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Ryuichiro Ishitani

12

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author name string

Yoshiki Tanaka

1

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Christopher J Hipolito

2

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Andrés D Maturana

3

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Koichi Ito

4

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Teruo Kuroda

5

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Takashi Higuchi

6

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Takayuki Katoh

7

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Hideaki E Kato

8

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Motoyuki Hattori

9

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Kaoru Kumazaki

10

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Tomoya Tsukazaki

11

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Hiroaki Suga

The multidrug efflux protein NorM is a prototype of a new family of transporters

13

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language of work or name

English

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publication date

11 April 2013

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published in

Nature

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volume

496

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issue

7444

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page(s)

247-51

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cites work

1 reference

An H( )-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa

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Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein

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A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline

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Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

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Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins

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Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine

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Structure of a bacterial multidrug ABC transporter

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Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

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NorM of vibrio parahaemolyticus is an Na( )-driven multidrug efflux pump

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Identification of essential amino acid residues of the NorM Na /multidrug antiporter in Vibrio parahaemolyticus

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Structure of a cation-bound multidrug and toxic compound extrusion transporter

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Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.

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Structures of a Na -coupled, substrate-bound MATE multidrug transporter

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Features and development of Coot

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Conserved motifs in prokaryotic and eukaryotic polypeptide release factors: tRNA-protein mimicry hypothesis

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Pressure-sensitive ion channel in Escherichia coli

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Patch clamp and phenotypic analyses of a prokaryotic cyclic nucleotide-gated K channel using Escherichia coli as a host

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Active efflux as the multidrug resistance mechanism

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12 December 2020

Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

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12 December 2020

Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects

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12 December 2020

NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli

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7 January 2021

inferred from DOI database lookup

Oppositely directed H gradient functions as a driving force of rat H /organic cation antiporter MATE1

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12 December 2020

Automated structure solution with autoSHARP

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