ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets (Q27683708)

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21 February 2020

title

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets (English)

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21 February 2020

11

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21 February 2020

Kylie D. Mason

20

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21 February 2020

Andrew W. Roberts

27

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21 February 2020

author name string

Andrew J Souers

1

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21 February 2020

Joel D Leverson

2

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21 February 2020

Erwin R Boghaert

3

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21 February 2020

Scott L Ackler

4

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21 February 2020

Nathaniel D Catron

5

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21 February 2020

Jun Chen

6

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21 February 2020

Brian D Dayton

7

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21 February 2020

Hong Ding

8

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21 February 2020

Sari H Enschede

9

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21 February 2020

Wayne J Fairbrother

10

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21 February 2020

Sarah G Hymowitz

12

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Sha Jin

13

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Seong Lin Khaw

14

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Peter J Kovar

15

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21 February 2020

Lloyd T Lam

16

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Jackie Lee

17

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Heather L Maecker

18

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Kennan C Marsh

19

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Michael J Mitten

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Paul M Nimmer

22

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Anatol Oleksijew

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Chang H Park

24

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Cheol-Min Park

25

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Darren C Phillips

26

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Deepak Sampath

28

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John F Seymour

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Morey L Smith

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Gerard M Sullivan

31

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Stephen K Tahir

32

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Chris Tse

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Michael D Wendt

34

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Yu Xiao

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John C Xue

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Haichao Zhang

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Rod A Humerickhouse

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Saul H Rosenberg

39

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Steven W Elmore

40

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language of work or name

English

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publication date

6 January 2013

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21 February 2020

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21 February 2020

volume

19

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21 February 2020

issue

2

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21 February 2020

page(s)

202-208

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21 February 2020

cites work

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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Solution structure of the antiapoptotic protein bcl-2

21 April 2017

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 April 2017

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 April 2017

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Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

21 April 2017

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Structural Plasticity in a Remodeled Protein-Protein Interface

21 April 2017

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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

21 April 2017

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miR-15 and miR-16 induce apoptosis by targeting BCL2

21 April 2017

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MiR-15a and miR-16-1 cluster functions in human leukemia

21 April 2017

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Development of a high-throughput fluorescence polarization assay for Bcl-x(L)

21 April 2017

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The BCL-2 protein family: opposing activities that mediate cell death

21 April 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 April 2017

1 reference

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 April 2017

1 reference

Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo

21 April 2017

1 reference

12 December 2020

Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction

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12 December 2020

BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma

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12 December 2020

New therapeutic targets and drugs in non-Hodgkinʼs lymphoma

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12 December 2020

Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53

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12 December 2020

Assays to measure p53-dependent and -independent apoptosis.

1 reference

12 December 2020

Bcl-2 inhibitors induce apoptosis in chronic lymphocytic leukemia cells

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12 December 2020

Predictive biomarkers: a paradigm shift towards personalized cancer medicine

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12 December 2020

VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic Leukemia

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12 December 2020

The management of tumor lysis syndrome.

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12 December 2020

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction

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12 December 2020

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

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12 December 2020

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

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12 December 2020

Bcl-2 family proteins are essential for platelet survival.

1 reference

12 December 2020

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

12 December 2020

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

1 reference

12 December 2020

The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile

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12 December 2020

Expression of bcl-xL can confer a multidrug resistance phenotype

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12 December 2020

Involvement of the bcl-2 gene in human follicular lymphoma

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12 December 2020

Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models

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12 December 2020

An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

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12 December 2020

Programmed anuclear cell death delimits platelet life span.

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12 December 2020

Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation.

1 reference

12 December 2020

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

1 reference

12 December 2020

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

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12 December 2020

Analysis of Bcl-2 protein expression in chronic lymphocytic leukemia. A comparison of three semiquantitation techniques

1 reference

12 December 2020

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1 reference

12 December 2020

mRNA display selection of a high-affinity, Bcl-X(L)-specific binding peptide

1 reference

12 December 2020

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

1 reference

12 December 2020

The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo.

1 reference

12 December 2020

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia.

1 reference

12 December 2020

Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3048

2 references

Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

21 February 2020

1041962027

0 references

Fatcat ID

release_by3qcitkjreyjox2p3ixiblrui

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Fatcat

https://api.fatcat.wiki/v0/release/by3qcitkjreyjox2p3ixiblrui

24 November 2022

mapped directly with Wikidata item

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

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