Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor (Q27680518)

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Christopher M Koth

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author name string

Susmith Mukund

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Yonglei Shang

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Holly J Clarke

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Azadeh Madjidi

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Jacob E Corn

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Lance Kates

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Ganesh Kolumam

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Vicky Chiang

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Elizabeth Luis

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Jeremy Murray

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Yingnan Zhang

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Bernard B Allan

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Journal of Biological Chemistry

4 June 2020

language of work or name

English

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publication date

13 December 2013

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published in

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volume

288

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issue

50

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page(s)

36168-36178

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Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

4 June 2020

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A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus

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Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists

20 March 2017

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Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant

20 March 2017

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Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor

20 March 2017

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HADDOCK versus HADDOCK: new features and performance of HADDOCK2.0 on the CAPRI targets

20 March 2017

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Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

7 April 2017

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Modulation of β-catenin signaling by glucagon receptor activation

29 September 2017

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Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

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29 September 2017

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29 September 2017

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Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans

2 June 2018

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Crossref

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Physiological and genetic characterization of the Gly40Ser mutation in the glucagon receptor gene in the Sardinian population. The Sardinian Diabetes Genetic Study Group

21 January 2018

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Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia

21 January 2018

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Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect?

21 January 2018

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27 November 2018

Identifiers

DOI

10.1074/JBC.M113.496984

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189067 AND SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189067 AND SRC:MED&resulttype=core&format=json

4 June 2020

PubMed publication ID

24189067

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24189067 AND SRC:MED&resulttype=core&format=json