Structural Studies on Dinuclear Ruthenium(II) Complexes That Bind Diastereoselectively to an Antiparallel Folded Human Telomere Sequence (Q27680131)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24088028 AND SRC:MED&resulttype=core&format=json

26 February 2020

title

Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence (English)

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26 February 2020

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26 February 2020

Vítor Félix

3

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26 February 2020

Mike P. Williamson

4

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26 February 2020

Jim A. Thomas

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26 February 2020

author name string

Tom Wilson

1

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26 February 2020

language of work or name

English

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publication date

23 October 2013

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Journal of Medicinal Chemistry

26 February 2020

published in

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26 February 2020

volume

56

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26 February 2020

issue

21

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26 February 2020

page(s)

8674-8683

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Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells

26 February 2020

cites work

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Crystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes

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Crystal structure of Δ-[Ru(bpy)2dppz]2 bound to mismatched DNA reveals side-by-side metalloinsertion and intercalation

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Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands

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Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes

20 March 2017

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Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

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Structure of Human Telomeric DNA in Crowded Solution

20 March 2017

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Structure of the Human Telomere in K Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

20 March 2017

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Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes

20 March 2017

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Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4

20 March 2017

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Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K solution: insights into structure polymorphism of the human telomeric sequence

20 March 2017

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Structural basis for binding of porphyrin to human telomeres

20 March 2017

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Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat

20 March 2017

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Structure of the first parallel DNA quadruplex-drug complex

20 March 2017

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Structure of a G-quadruplex-ligand complex

20 March 2017

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Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

20 March 2017

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Crystal structure of parallel quadruplexes from human telomeric DNA

20 March 2017

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Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex

20 March 2017

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

20 March 2017

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In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

20 March 2017

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Quantitative visualization of DNA G-quadruplex structures in human cells

20 March 2017

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Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo

20 March 2017

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Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

20 March 2017

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Development and testing of a general amber force field

20 March 2017

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Refinement of the AMBER force field for nucleic acids: improving the description of alpha/gamma conformers

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7 April 2017

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Stabilization of G-quadruplex DNA, inhibition of telomerase activity and live cell imaging studies of chiral ruthenium(II) complexes

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

29 September 2017

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Interaction of metal complexes with G-quadruplex DNA.

29 September 2017

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Structure of the complex of [Ru(tpm)(dppz)py](2 ) with a B-DNA oligonucleotide - a single-substituent binding switch for a metallo-intercalator.

29 September 2017

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The structures of quadruplex nucleic acids and their drug complexes

29 September 2017

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Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA.

29 September 2017

1 reference

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G-quadruplexes: targets in anticancer drug design.

29 September 2017

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Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription

29 September 2017

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Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.

29 September 2017

1 reference

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An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation

29 September 2017

1 reference

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Structure of the human telomere in K solution: an intramolecular (3 1) G-quadruplex scaffold

29 September 2017

1 reference

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Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution

29 September 2017

1 reference

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G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

29 September 2017

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An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution

29 September 2017

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Helix formation by guanylic acid

29 September 2017

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Kinetically inert transition metal complexes that reversibly bind to DNA.

29 September 2017

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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

29 September 2017

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NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

29 September 2017

1 reference

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Inhibition of telomerase by G-quartet DNA structures

29 September 2017

1 reference

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Initial DNA interactions of the binuclear threading intercalator Λ,Λ-[μ-bidppz(bipy)4Ru2]4 : an NMR study with [d(CGCGAATTCGCG)]2.

29 September 2017

1 reference

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The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions.

2 June 2018

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Arrangements of human telomere DNA quadruplex in physiologically relevant K solutions

2 June 2018

1 reference

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G-quadruplexes in promoters throughout the human genome

2 June 2018

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Chiral metallo-supramolecular complexes selectively induce human telomeric G-quadruplex formation under salt-deficient conditions.

2 June 2018

1 reference

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Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(II) complex with four-stranded DNA structures

27 November 2018

1 reference

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A chiral wedge molecule inhibits telomerase activity.

27 November 2018

1 reference

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Combined QM/MM and classical molecular dynamics study of [Ru(bpy)3]2 in water

27 November 2018

1 reference

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Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species.

27 November 2018

1 reference

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Dinuclear monointercalating RuII complexes that display high affinity binding to duplex and quadruplex DNA.

27 November 2018

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Stereoselectivity for DNA Threading Intercalation of Short Binuclear Ruthenium Complexes

27 November 2018

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12 December 2020

The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

1 reference

12 December 2020

Human telomeric DNA forms parallel-stranded intramolecular G-quadruplex in K solution under molecular crowding condition

1 reference

12 December 2020

Bridging ligand length controls at selectivity and enantioselectivity of binuclear ruthenium threading intercalators

1 reference

12 December 2020

Molecular Mechanics (MM3) Parameters for Ruthenium(II)-Polypyridyl Complexes

1 reference

12 December 2020

Interaction of [Ru(bpy)2(dppz)]2 with human telomeric DNA: Preferential binding to G-quadruplexes over i-motif

1 reference

12 December 2020

Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3' sequence of d(AG3(TTAG3)3)

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM401119B

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24088028 AND SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24088028 AND SRC:MED&resulttype=core&format=json

26 February 2020

PubMed publication ID

24088028

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24088028 AND SRC:MED&resulttype=core&format=json