Active Site Conformational Dynamics Are Coupled to Catalysis in the mRNA Decapping Enzyme Dcp2 (Q27679348)

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6 March 2020

title

Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2 (English)

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6 March 2020

0 references

2

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6 March 2020

Matthew P. Jacobson

4

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6 March 2020

author name string

Robin A Aglietti

1

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6 March 2020

Chris L McClendon

3

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6 March 2020

John D Gross

5

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publication date

1 August 2013

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6 March 2020

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6 March 2020

volume

21

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issue

9

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page(s)

1571-1580

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A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation

6 March 2020

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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mRNA decapping is promoted by an RNA-binding channel in Dcp2

20 March 2017

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

20 March 2017

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Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping

20 March 2017

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Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme

20 March 2017

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Functional characterization of the mammalian mRNA decapping enzyme hDcp2

20 March 2017

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Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

20 March 2017

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The hDcp2 protein is a mammalian mRNA decapping enzyme

20 March 2017

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The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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The DEAD-box protein Dhh1 promotes decapping by slowing ribosome movement

20 March 2017

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Identification of a quality-control mechanism for mRNA 5'-end capping

20 March 2017

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Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe

20 March 2017

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The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif

20 March 2017

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A 5'----3' exoribonuclease of Saccharomyces cerevisiae: size and novel substrate specificity

20 March 2017

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Characterization of active-site residues in diadenosine tetraphosphate hydrolase from Lupinus angustifolius

20 March 2017

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20 March 2017

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An essential component of the decapping enzyme required for normal rates of mRNA turnover

20 March 2017

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7 April 2017

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Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.

29 September 2017

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Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7.

29 September 2017

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A split active site couples cap recognition by Dcp2 to activation

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Decapping is preceded by 3' uridylation in a novel pathway of bulk mRNA turnover

29 September 2017

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29 September 2017

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Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing

29 September 2017

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29 September 2017

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29 September 2017

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Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae

29 September 2017

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29 September 2017

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29 September 2017

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Functional link between the mammalian exosome and mRNA decapping

29 September 2017

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29 September 2017

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Individual ionization constants of all the carboxyl groups in ribonuclease HI from Escherichia coli determined by NMR.

29 September 2017

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mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation

29 September 2017

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29 September 2017

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27 November 2018

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27 November 2018

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27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23911090

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23911090

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Determination of the side chain pKa values of the lysine residues in calmodulin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23911090

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.STR.2013.06.021

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23911090 AND SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23911090 AND SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

23911090

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23911090 AND SRC:MED&resulttype=core&format=json