Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131 (Q27678516)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23744091 AND SRC:MED&resulttype=core&format=json

2 March 2020

title

Engineered antibody Fc variant with selectively enhanced FcγRIIb binding over both FcγRIIa(R131) and FcγRIIa(H131) (English)

1 reference

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2 March 2020

0 references

1 reference

8

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2 March 2020

author name string

F Mimoto

1

1 reference

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2 March 2020

H Katada

2

1 reference

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2 March 2020

S Kadono

3

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2 March 2020

T Igawa

4

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2 March 2020

T Kuramochi

5

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2 March 2020

M Muraoka

6

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2 March 2020

Y Wada

7

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2 March 2020

T Miyazaki

9

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2 March 2020

K Hattori

10

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2 March 2020

publication date

5 June 2013

1 reference

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Protein Engineering Design and Selection

2 March 2020

published in

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2 March 2020

volume

26

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2 March 2020

issue

10

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2 March 2020

page(s)

589-598

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Translating basic mechanisms of IgG effector activity into next generation cancer therapies

2 March 2020

cites work

1 reference

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CD19 as an attractive target for antibody-based therapy

20 March 2017

1 reference

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Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

20 March 2017

1 reference

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Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions

20 March 2017

1 reference

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REFMAC5 for the refinement of macromolecular crystal structures

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

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20 March 2017

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Phasercrystallographic software

20 March 2017

1 reference

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Scaling and assessment of data quality

20 March 2017

1 reference

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Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab

20 March 2017

1 reference

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Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by FcgammaRIIb2

20 March 2017

1 reference

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Fcgamma receptors as regulators of immune responses

20 March 2017

1 reference

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FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs.

7 April 2017

1 reference

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Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcγ receptor engagement

29 September 2017

1 reference

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Mouse model recapitulating human Fcγ receptor structural and functional diversity

29 September 2017

1 reference

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Inhibitory Fcγ Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

29 September 2017

1 reference

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An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells

29 September 2017

1 reference

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Non-classical binding of a polyreactive α-type anti-idiotypic antibody to B cells.

29 September 2017

1 reference

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Anti-CD40L immune complexes potently activate platelets in vitro and cause thrombosis in FCGR2A transgenic mice

29 September 2017

1 reference

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Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Bevacizumab immune complexes activate platelets and induce thrombosis in FCGR2A transgenic mice

29 September 2017

1 reference

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FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.

29 September 2017

1 reference

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Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells

29 September 2017

1 reference

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Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies

29 September 2017

1 reference

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Monoclonal antibody "gold rush".

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Modulation of the effector functions of a human IgG1 through engineering of its hinge region

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Divergent immunoglobulin g subclass activity through selective Fc receptor binding

29 September 2017

1 reference

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The regulation of lymphocyte activation by inhibitory receptors

29 September 2017

1 reference

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Feedback regulation by IgG antibodies.

29 September 2017

1 reference

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Therapeutic antibodies for human diseases at the dawn of the twenty-first century

29 September 2017

1 reference

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Variant genotypes of the low-affinity Fcgamma receptors in two control populations and a review of low-affinity Fcgamma receptor polymorphisms in control and disease populations.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

4-1BB costimulatory signals preferentially induce CD8 T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses

29 September 2017

1 reference

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Divergent intracellular sorting of Fc{gamma}RIIA and Fc{gamma}RIIB2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Deglycosylation of proteins for crystallization using recombinant fusion protein glycosidases

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Antibodies against growth factor receptors can inhibit the proliferation of transformed cells via a cis-interaction with inhibitory FcR.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Reduced elimination of IgG antibodies by engineering the variable region

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

High throughput thermostability screening of monoclonal antibody formulations

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

Ethnic variation in frequency of an allelic polymorphism of human Fc gamma RIIA determined with allele specific oligonucleotide probes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3785249

The impact of Fc engineering on an anti-CD19 antibody: increased Fcgamma receptor affinity enhances B-cell clearing in nonhuman primates

27 November 2018

1 reference

12 December 2020

Cell surface recycling of internalized antigen permits dendritic cell priming of B cells

1 reference

12 December 2020

Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus

1 reference

12 December 2020

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

1 reference

12 December 2020

Immune complex enhances tolerogenecity of immature dendritic cells via FcγRIIb and promotes FcγRIIb‐overexpressing dendritic cells to attenuate lupus

1 reference

12 December 2020

Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses

1 reference

12 December 2020

Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb

1 reference

12 December 2020

Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors

1 reference

12 December 2020

Intravenous immunoglobulins induce CD32-mediated platelet aggregation in vitro

1 reference

12 December 2020

A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis

1 reference

12 December 2020

Identifiers

DOI

10.1093/PROTEIN/GZT022

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23744091 AND SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23744091 AND SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

23744091

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23744091 AND SRC:MED&resulttype=core&format=json