Using a Fragment-Based Approach To Target Protein-Protein Interactions (Q27675981)

3

Tara Pukala

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May Marsh

May Marsh

4

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Tom Blundell

5

Tom L Blundell

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Matthias T Ehebauer

2

Matthias T Ehebauer

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author name string

Duncan E Scott

1

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Ashok R Venkitaraman

6

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Marko Hyvönen

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

8

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publication date

11 February 2013

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published in

ChemBioChem

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volume

14

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issue

3

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page(s)

332-42

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cites work

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Purified human BRCA2 stimulates RAD51-mediated recombination

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Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design

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Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

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Site-directed ligand discovery

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The atomic structure of protein-protein recognition sites

20 March 2017

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Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database

20 March 2017

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

20 March 2017

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A hot spot of binding energy in a hormone-receptor interface

7 April 2017

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Rapid measurement of binding constants and heats of binding using a new titration calorimeter

7 April 2017

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Ligand efficiency: a useful metric for lead selection

7 April 2017

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery

7 April 2017

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Thermodynamics of fragment binding.

29 September 2017

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Fragment screening using X-ray crystallography.

29 September 2017

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Predictions of hot spot residues at protein-protein interfaces using support vector machines.

29 September 2017

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29 September 2017

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Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

29 September 2017

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The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

29 September 2017

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29 September 2017

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Structural biology in fragment-based drug design

29 September 2017

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Discovery of a new series of Aurora inhibitors through truncation of GSK1070916.

29 September 2017

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Assessing the druggability of protein-protein interactions by a supervised machine-learning method

29 September 2017

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Predicting druggable binding sites at the protein-protein interface.

29 September 2017

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Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

29 September 2017

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Fragment-based approaches to enzyme inhibition

29 September 2017

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Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

29 September 2017

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Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery

29 September 2017

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Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

29 September 2017

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Target structure-based discovery of small molecules that block human p53 and CREB binding protein association

29 September 2017

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29 September 2017

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Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites

2 June 2018

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21 January 2018

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21 January 2018

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A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

21 January 2018

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On the value of c: can low affinity systems be studied by isothermal titration calorimetry?

21 January 2018

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The influence of drug-like concepts on decision-making in medicinal chemistry

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Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23344974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T7 vectors with modified T7lac promoter for expression of proteins in Escherichia coli

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23344974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CBIC.201200521

1 reference

1 reference

1 reference

PubMed publication ID

23344974

1 reference