NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling (Q27675552)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22081014 AND SRC:MED&resulttype=core&format=json

16 January 2020

title

NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling (English)

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16 January 2020

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1

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16 January 2020

Yann Wallez

2

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16 January 2020

author name string

Małgorzata K Dobaczewska

3

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16 January 2020

Jeongeun J Lee

4

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16 January 2020

Howard Robinson

5

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16 January 2020

Elena B Pasquale

6

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16 January 2020

Stefan J Riedl

7

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16 January 2020

language of work or name

English

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publication date

13 November 2011

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Nature Structural & Molecular Biology

16 January 2020

published in

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16 January 2020

volume

18

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16 January 2020

issue

12

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16 January 2020

page(s)

1381-1387

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Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2

16 January 2020

cites work

1 reference

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Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

20 March 2017

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20 March 2017

Paxillin comes of age

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Structural analysis of autoinhibition in the Ras activator Son of sevenless

20 March 2017

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Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain

20 March 2017

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

20 March 2017

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BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells

20 March 2017

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NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway

20 March 2017

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The structural basis of the activation of Ras by Sos

20 March 2017

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Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells

20 March 2017

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Integrin signalling adaptors: not only figurants in the cancer story

20 March 2017

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SHEP1 partners with CasL to promote marginal zone B-cell maturation

20 March 2017

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Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance

20 March 2017

1 reference

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A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A

20 March 2017

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Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1

20 March 2017

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A Ras-induced conformational switch in the Ras activator Son of sevenless

20 March 2017

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LKB1 modulates lung cancer differentiation and metastasis

20 March 2017

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BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.

24 May 2017

1 reference

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The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas

29 September 2017

1 reference

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BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling

29 September 2017

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Regulation of T-lymphocyte physiology by the Chat-H/CasL adapter complex

29 September 2017

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Functional identification of genes causing estrogen independence of human breast cancer cells

29 September 2017

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Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling

29 September 2017

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Characterization of AND-34 function and signaling.

29 September 2017

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Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

29 September 2017

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SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases

29 September 2017

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Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.

29 September 2017

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The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.

29 September 2017

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Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.

29 September 2017

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29 September 2017

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Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways

29 September 2017

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The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin

29 September 2017

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AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines.

29 September 2017

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The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.

29 September 2017

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2 June 2018

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Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).

2 June 2018

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p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

2 June 2018

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The adaptor protein Sh2d3c is critical for marginal zone B cell development and function

21 January 2018

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21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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Likelihood-enhanced fast rotation functions

21 January 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

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Coot: model-building tools for molecular graphics

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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Comparison of sequence profiles. Strategies for structural predictions using sequence information

21 January 2018

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Protein structure modeling with MODELLER

21 January 2018

1 reference

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

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Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

21 January 2018

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Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

21 January 2018

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Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements

21 January 2018

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31 March 2020

Identifiers

DOI

10.1038/NSMB.2152

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22081014 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

16 January 2020

1037414192

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22081014 AND SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

22081014

2 references