Structural Basis for Methyl Transfer by a Radical SAM Enzyme (Q27667611)

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30 January 2020

title

Structural basis for methyl transfer by a radical SAM enzyme (English)

1 reference

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rRNA (adenine-C2-)-methyltransferase activity

30 January 2020

main subject

1 reference

Gene Ontology release 2020-05-02

3

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6

Amy C Rosenzweig

1 reference

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30 January 2020

1

Amie K Boal

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30 January 2020

author name string

Tyler L Grove

series ordinal

2

1 reference

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30 January 2020

Neela H Yennawar

series ordinal

4

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30 January 2020

Squire J Booker

series ordinal

5

1 reference

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30 January 2020

language of work or name

English

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publication date

28 April 2011

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30 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21527678 AND SRC:MED&resulttype=core&format=json

30 January 2020

volume

332

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issue

6033

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page(s)

1089-1092

1 reference

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RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

30 January 2020

cites work

1 reference

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Structure of the RNA Binding Domain of a DEAD-Box Helicase Bound to Its Ribosomal RNA Target Reveals a Novel Mode of Recognition by an RNA Recognition Motif

20 March 2017

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RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

20 March 2017

1 reference

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Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

20 March 2017

1 reference

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Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA

20 March 2017

1 reference

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Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins

20 March 2017

1 reference

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Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

20 March 2017

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Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

20 March 2017

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X-ray structure of the [FeFe]-hydrogenase maturase HydE from Thermotoga maritima

20 March 2017

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The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

20 March 2017

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Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme

20 March 2017

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Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes

20 March 2017

1 reference

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Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain

20 March 2017

1 reference

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Structural basis for allosteric substrate specificity regulation in anaerobic ribonucleotide reductases

20 March 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

20 March 2017

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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

20 March 2017

1 reference

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Structure and mechanism of the glycyl radical enzyme pyruvate formate-lyase

20 March 2017

1 reference

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Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance

20 March 2017

1 reference

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Hyperfine-Shifted 13C Resonance Assignments in an Iron−Sulfur Protein with Quantum Chemical Verification: Aliphatic C−H···S 3-Center−4-Electron Interactions

29 September 2017

1 reference

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The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

29 September 2017

1 reference

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Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection

29 September 2017

1 reference

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Anaerobic functionalization of unactivated C-H bonds

29 September 2017

1 reference

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Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors

29 September 2017

1 reference

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The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

29 September 2017

1 reference

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Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism

29 September 2017

1 reference

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Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans

29 September 2017

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AdoMet radical proteins--from structure to evolution--alignment of divergent protein sequences reveals strong secondary structure element conservation

29 September 2017

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The generation of 5′-deoxyadenosyl radicals by adenosylmethionine-dependent radical enzymes

29 September 2017

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Radical mechanisms of S-adenosylmethionine-dependent enzymes

29 September 2017

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Adenosylmethionine as a source of 5'-deoxyadenosyl radicals

29 September 2017

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Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri

29 September 2017

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Common fold in helix-hairpin-helix proteins

29 September 2017

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A 9 A resolution X-ray crystallographic map of the large ribosomal subunit

29 September 2017

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Isotope and elemental effects indicate a rate-limiting methyl transfer as the initial step in the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase

2 June 2018

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A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

21 January 2018

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Posttranscriptional modification of the central loop of domain V in Escherichia coli 23 S ribosomal RNA.

21 January 2018

1 reference

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Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid

21 January 2018

1 reference

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A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

21 January 2018

1 reference

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Direct FeS cluster involvement in generation of a radical in lysine 2,3-aminomutase

21 January 2018

1 reference

12 December 2020

Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase

1 reference

12 December 2020

The Radical SAM Superfamily

1 reference

12 December 2020

Fomenting proton anisochronicity in the CH2D group

1 reference

12 December 2020

A Glycyl Radical Site in the Crystal Structure of a Class III Ribonucleotide Reductase

1 reference

12 December 2020

Regioselectivity in the Homolytic Cleavage of S-Adenosylmethionine

1 reference

12 December 2020

Identifiers

DOI

10.1126/SCIENCE.1205358

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21527678 AND SRC:MED&resulttype=core&format=json

30 January 2020

ADS bibcode

2011Sci...332.1089B

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21527678 AND SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

21527678

2 references