Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase (Q27666032)

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16 January 2020

title

Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase (English)

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16 January 2020

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4

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16 January 2020

author name string

Greg Buhrman

1

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16 January 2020

V S Senthil Kumar

2

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16 January 2020

Murat Cirit

3

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16 January 2020

Carla Mattos

5

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16 January 2020

language of work or name

English

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publication date

22 November 2010

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Journal of Biological Chemistry

16 January 2020

number of pages

9

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inferred from page(s)

published in

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16 January 2020

volume

286

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16 January 2020

issue

5

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16 January 2020

page(s)

3323-3331

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Allosteric modulation of Ras positions Q61 for a direct role in catalysis

16 January 2020

cites work

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Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf

20 March 2017

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20 March 2017

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Organic solvents order the dynamic switch II in Ras crystals

20 March 2017

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

20 March 2017

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The structural basis of the activation of Ras by Sos

20 March 2017

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20 March 2017

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The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

20 March 2017

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20 March 2017

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20 March 2017

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Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

20 March 2017

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

20 March 2017

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Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

20 March 2017

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Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

20 March 2017

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20 March 2017

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20 March 2017

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Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues

20 March 2017

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20 March 2017

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

20 March 2017

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Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.

7 April 2017

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Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects

29 September 2017

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KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer.

29 September 2017

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PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk

29 September 2017

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Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: evidence for a loose transition state

29 September 2017

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The dark side of Ras: regulation of apoptosis

29 September 2017

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Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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2 June 2018

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19 June 2018

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19 June 2018

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NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation

27 November 2018

1 reference

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Processing of X-ray diffraction data collected in oscillation mode

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21098031

inferred from PubMed ID database lookup

12 December 2020

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Identifiers

DOI

10.1074/JBC.M110.193854

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21098031 AND SRC:MED&resulttype=core&format=json

16 January 2020

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16 January 2020

PubMed publication ID

21098031

2 references