Active Site Conformational Dynamics in Human Uridine Phosphorylase 1 (Q27664610)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Samantha Castronovo

series ordinal

2

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Tarmo P. Roosild

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20856879

full work available at URL

17 July 2024

language of work or name

English

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publication date

14 September 2010

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012741&type=printable

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20856879

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20856879/?tool=EBI

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20856879

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20856879/pdf/?tool=EBI

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20856879

https://europepmc.org/articles/PMC2939078

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20856879

https://europepmc.org/articles/PMC2939078?pdf=render

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20856879

http://dx.plos.org/10.1371/journal.pone.0012741

17 July 2024

1 reference

10.1371/JOURNAL.PONE.0012741

DOI

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0012741

17 July 2024

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5

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issue

9

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page(s)

e12741

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copyright license

Creative Commons Attribution 4.0 International

start time

14 September 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Uridine phosphorylase association with vimentin. Intracellular distribution and localization

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Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase

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Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase

20 March 2017

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Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

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Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

29 September 2017

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Expression, characterization, and detection of human uridine phosphorylase and identification of variant uridine phosphorolytic activity in selected human tumors.

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29 September 2017

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Crystal structures of Escherichia coli uridine phosphorylase in two native and three complexed forms reveal basis of substrate specificity, induced conformational changes and influence of potassium

21 January 2018

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Crystallization and preliminary X-ray diffraction analysis of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Uridine prevents the glucose deprivation-induced death of immunostimulated astrocytes via the action of uridine phosphorylase

21 January 2018

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Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.

21 January 2018

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Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines

27 November 2018

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Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20856879

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20856879

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0012741

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