Conformational switch triggered by &#160;-ketoglutarate in a halogenase of curacin A biosynthesis (Q27663614)

5

David H Sherman

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Janet L. Smith

8

Janet L Smith

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Kristina Hakansson

7

Kristina Håkansson

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Jamie R Razelun

4

Jamie Razelun

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Dheeraj Khare

1

Dheeraj Khare

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author name string

Bo Wang

2

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Liangcai Gu

Proceedings of the National Academy of Sciences of the United States of America

3

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language of work or name

English

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publication date

10 August 2010

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published in

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volume

107

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issue

32

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page(s)

14099-104

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cites work

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Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

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Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

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Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

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SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase

29 September 2017

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Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula

29 September 2017

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Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula

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Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues.

29 September 2017

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Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry

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Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

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Biosynthesis of radiolabeled curacin A and its rapid and apparently irreversible binding to the colchicine site of tubulin.

21 January 2018

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Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.

21 January 2018

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Crystal structure of the alkylsulfatase AtsK: insights into the catalytic mechanism of the Fe(II) alpha-ketoglutarate-dependent dioxygenase superfamily

21 January 2018

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Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

21 January 2018

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Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis

21 January 2018

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Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20660778

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1006738107

1 reference

release_txxy7ihk5vhfpi43tovrxhb7a4

0 references

0 references

1819064

1 reference

1 reference

1819064

PubMed publication ID

20660778

1 reference