Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant (Q27658903)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062057 AND SRC:MED&resulttype=core&format=json

16 January 2020

title

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant (English)

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16 January 2020

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Samantha Perez-Miller

1

1 reference

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16 January 2020

Hina Younus

2

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16 January 2020

author name string

Ram Vanam

3

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16 January 2020

Che-Hong Chen

4

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16 January 2020

Thomas D Hurley

6

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16 January 2020

Daria Mochly-Rosen

5

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16 January 2020

publication date

10 January 2010

1 reference

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Nature Structural & Molecular Biology

16 January 2020

published in

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16 January 2020

volume

17

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16 January 2020

issue

2

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16 January 2020

page(s)

159-164

1 reference

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The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption

16 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857674

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

20 March 2017

1 reference

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Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase

20 March 2017

1 reference

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Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: ROLES OF RESIDUES 475 AND 487

20 March 2017

1 reference

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An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857674

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

20 March 2017

1 reference

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Human liver mitochondrial aldehyde dehydrogenase: Three-dimensional structure and the restoration of solubility and activity of chimeric forms

20 March 2017

1 reference

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The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity

20 March 2017

1 reference

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The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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PHENIX: building new software for automated crystallographic structure determination

20 March 2017

2 references

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20 March 2017

Aldehyde dehydrogenase genotypes in Japanese alcoholics

22 April 2017

1 reference

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Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities

20 March 2017

1 reference

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Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase.

29 September 2017

1 reference

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The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis.

29 September 2017

1 reference

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Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.

29 September 2017

1 reference

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Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857674

Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857674

Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857674

A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men.

2 June 2018

1 reference

Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase

21 January 2018

1 reference

Nicotinamide adenine dinucleotide activation of the esterase reaction of horse liver aldehyde dehydrogenase.

21 January 2018

1 reference

ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties

21 January 2018

1 reference

Evidence for the chemical activation of essential cys-302 upon cofactor binding to nonphosphorylating glyceraldehyde 3-phosphate dehydrogenase from Streptococcus mutans

21 January 2018

1 reference

Human mitochondrial aldehyde dehydrogenase substrate specificity: comparison of esterase with dehydrogenase reaction

31 March 2020

1 reference

Processing of X-ray diffraction data collected in oscillation mode

31 March 2020

1 reference

Horse liver aldehyde dehydrogenase. II. Kinetics and mechanistic implications of the dehydrogenase and esterase activity

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20062057

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1737

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062057 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

16 January 2020

1004318308

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20062057 AND SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

20062057

2 references