N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis (Q27658775)

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English	N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis	scientific article

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scholarly article

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30 August 2019

N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis (English)

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30 August 2019

N-myristoyltransferase

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visceral leishmaniasis

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based on heuristic

inferred from title

Leishmania donovani

object named as

Leishmania donovani

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based on heuristic

inferred from title

10

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30 August 2019

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30 August 2019

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Helen P Price

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30 August 2019

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James A Brannigan

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30 August 2019

Barbara A Smith

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30 August 2019

Zhiyong Yu

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30 August 2019

Andrzej M Brzozowski

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30 August 2019

Michael R Hodgkinson

5

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30 August 2019

Asher Maroof

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30 August 2019

Franziska Meier

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30 August 2019

Robin J Leatherbarrow

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30 August 2019

Deborah F Smith

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30 August 2019

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28 December 2009

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30 August 2019

Journal of Molecular Biology

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30 August 2019

396

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30 August 2019

4

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30 August 2019

985-999

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20036251 AND SRC:MED&resulttype=core&format=json

30 August 2019

Comparative genomic analysis of three Leishmania species that cause diverse human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

20 March 2017

Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

20 March 2017

Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

20 March 2017

Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

20 March 2017

Crystal structure of the anti-fungal target N-myristoyl transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

20 March 2017

Protein production by auto-induction in high density shaking cultures

1 reference

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20 March 2017

Developments in the CCP4 molecular-graphics project

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20 March 2017

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

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20 March 2017

An approach to multi-copy search in molecular replacement

1 reference

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20 March 2017

ESPript: analysis of multiple sequence alignments in PostScript

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20 March 2017

The structure of myristoyl-CoA:protein N-myristoyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

20 March 2017

4-oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

20 March 2017

Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

7 April 2017

Drug resistance in leishmaniasis

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7 April 2017

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

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7 April 2017

ARP/wARP and molecular replacement: the next generation

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29 September 2017

The leishmaniases--survival and expansion in a changing world. A mini-review

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29 September 2017

Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis.

1 reference

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29 September 2017

Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania

1 reference

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29 September 2017

Current scenario of drug development for leishmaniasis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

29 September 2017

Recent improvements to the PROSITE database

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29 September 2017

Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8 T-cell responses.

1 reference

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29 September 2017

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

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29 September 2017

Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis

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29 September 2017

Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

29 September 2017

Immunocytochemical characterization and subcellular localization of human myristoyl-CoA: protein N-myristoyltransferase in HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

29 September 2017

Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans

1 reference

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29 September 2017

Genetic and biochemical studies of protein N-myristoylation

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29 September 2017

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829124

2 June 2018

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

1 reference

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2 June 2018

Comparison of the acyl chain specificities of human myristoyl-CoA synthetase and human myristoyl-CoA:protein N-myristoyltransferase

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2 June 2018

Isothermal titration calorimetric studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Determinants of binding energy and catalytic discrimination among acyl-CoA and peptide ligands.

1 reference

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2 June 2018

Disruption of the yeast N-myristoyl transferase gene causes recessive lethality.

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2 June 2018

Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase

1 reference

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2 June 2018

Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects.

1 reference

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27 November 2018

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

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27 November 2018

FTR1335 is a novel synthetic inhibitor of Candida albicans N-myristoyltransferase with fungicidal activity

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27 November 2018

Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites.

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27 November 2018

N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence

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27 November 2018

Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis

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27 November 2018

Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20036251

12 December 2020

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Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain

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12 December 2020

based on heuristic

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Acylation-dependent Protein Export in Leishmania

1 reference

https://pubmed.ncbi.nlm.nih.gov/20036251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.JMB.2009.12.032

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Consolidated OpenCitations Corpus – April 2017

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30 August 2019

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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30 August 2019

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

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