Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation (Q27654261)

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24 January 2020

title

Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation (English)

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2

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Rey-Ting Guo

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Kilannin Krysiak

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Andrew H-J Wang

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Eric Oldfield

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author name string

Yonghui Zhang

1

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Fenglin Yin

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Michael P Hudock

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Sujoy Mukherjee

7

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Yi-Gui Gao

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Howard Robinson

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Yongcheng Song

10

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Joo Hwan No

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Kyle Bergan

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Annette Leon

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Lauren Cass

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Amanda Goddard

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Ting-Kai Chang

16

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Fu-Yang Lin

17

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Ermond Van Beek

18

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Socrates Papapoulos

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Tadahiko Kubo

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Mitsuo Ochi

22

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Dushyant Mukkamala

23

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language of work or name

English

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publication date

1 April 2009

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Journal of the American Chemical Society

24 January 2020

published in

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volume

131

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issue

14

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page(s)

5153-5162

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Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases

24 January 2020

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The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

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Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data

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Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells

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Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells

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Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells

29 September 2017

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A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.

29 September 2017

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Bisphosphonates and cancer-induced bone disease: beyond their antiresorptive activity

29 September 2017

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29 September 2017

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29 September 2017

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2 June 2018

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27 November 2018

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27 November 2018

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27 November 2018

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27 November 2018

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Identifiers

DOI

10.1021/JA808285E

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137 AND SRC:MED&resulttype=core&format=json

release_yza4syjhgralzbsft362nlndxq

24 January 2020

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/yza4syjhgralzbsft362nlndxq

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mapped directly with Wikidata item

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2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19309137 AND SRC:MED&resulttype=core&format=json

24 January 2020

PubMed publication ID

19309137

2 references