Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome (Q27652801)

1

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Cajetan Neubauer

Cajetan Neubauer

3

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Rebecca Voorhees

Rebecca M Voorhees

4

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Venkatraman Ramakrishnan

Venki Ramakrishnan

7

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Ann C Kelley

6

Ann C Kelley

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author name string

Hong Jin

2

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Ann C Kelley

Structural basis for translation termination on the 70S ribosome

6

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language of work or name

English

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publication date

7 November 2008

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published in

Science

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volume

322

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issue

5903

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page(s)

953-6

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cites work

1 reference

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Release Factors 2 from Escherichia coli and Thermus thermophilus: structural, spectroscopic and microcalorimetric studies

20 March 2017

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Structure of the Escherichia coli ribosomal termination complex with release factor 2

20 March 2017

1 reference

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A cryo-electron microscopic study of ribosome-bound termination factor RF2

20 March 2017

1 reference

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Selection of tRNA by the ribosome requires a transition from an open to a closed form

20 March 2017

1 reference

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Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1

20 March 2017

1 reference

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

20 March 2017

1 reference

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The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis

20 March 2017

1 reference

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Structure of the 70S ribosome complexed with mRNA and tRNA

20 March 2017

1 reference

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Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate

20 March 2017

1 reference

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Peptide release on the ribosome: mechanism and implications for translational control

29 September 2017

1 reference

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Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination

29 September 2017

1 reference

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An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.

29 September 2017

1 reference

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Structural insights into translational fidelity

29 September 2017

1 reference

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Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3.

29 September 2017

1 reference

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A post-translational modification in the GGQ motif of RF2 from Escherichia coli stimulates termination of translation

29 September 2017

1 reference

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The accuracy of codon recognition by polypeptide release factors

29 September 2017

1 reference

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Single amino acid substitution in prokaryote polypeptide release factor 2 permits it to terminate translation at all three stop codons

29 September 2017

1 reference

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Polypeptide chain termination in vitro: isolation of a release factor

29 September 2017

1 reference

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An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination.

29 September 2017

1 reference

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The SAXS solution structure of RF1 differs from its crystal structure and is similar to its ribosome bound cryo-EM structure

2 June 2018

1 reference

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Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.

2 June 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1164840

Functional sites of interaction between release factor RF1 and the ribosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1164840

Stop codon recognition by release factors induces structural rearrangement of the ribosomal decoding center that is productive for peptide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1164840

Two distinct components of release factor function uncovered by nucleophile partitioning analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1164840

A model for how ribosomal release factors induce peptidyl-tRNA cleavage in termination of protein synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1164840

Deletion of a conserved, central ribosomal intersubunit RNA bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1164840

Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642913

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642913

A tripeptide 'anticodon' deciphers stop codons in messenger RNA.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642913

The essential role of the invariant GGQ motif in the function and stability in vivo of bacterial release factors RF1 and RF2

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18988853

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1164840

1 reference

1 reference

1 reference

PubMed publication ID

18988853

1 reference