In situ assembly of enzyme inhibitors using extended tethering (Q27640418)

2

object named as

Joni W Lam

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author name string

Daniel A Erlanson

1

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Christian Wiesmann

3

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Tinh N Luong

4

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Robert L Simmons

5

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Warren L DeLano

6

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Matthew T Burdett

8

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W Michael Flanagan

9

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Dennis Lee

10

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Eric M Gordon

11

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Tom O'Brien

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

12

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publication date

March 2003

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published in

Nature Biotechnology

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volume

21

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issue

3

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page(s)

308-14

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cites work

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Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

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Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.

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From bench to clinic with apoptosis-based therapeutic agents

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Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury

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Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

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Inhibition of human caspases by peptide-based and macromolecular inhibitors

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Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

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6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity

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Quiescent affinity inactivators of protein tyrosine phosphatases

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Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

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Dynamic combinatorial chemistry

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Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

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Selective inactivation of protein tyrosine phosphatase PTP1B by sulfone analogue of naphthoquinone

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A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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7 January 2021

P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta-converting enzyme

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7 January 2021

Binding of small molecules to an adaptive protein-protein interface

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7 January 2021

Mechanism-based inactivation of prostatic acid phosphatase

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Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones

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7 January 2021