Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy (Q27640250)

6 July 2017

title

Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy (English)

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6 July 2017

4

Celia A Schiffer

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6 July 2017

author name string

Moses Prabu-Jeyabalan

series ordinal

1

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6 July 2017

Ellen A Nalivaika

series ordinal

2

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6 July 2017

Nancy M King

series ordinal

3

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6 July 2017

language of work or name

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1 January 2003

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6 July 2017

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6 July 2017

volume

77

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6 July 2017

issue

2

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6 July 2017

page(s)

1306-1315

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Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes

6 July 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates

20 March 2017

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Three-dimensional structures of HIV-1 and SIV protease product complexes

20 March 2017

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Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases

20 March 2017

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Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase

20 March 2017

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ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans

20 March 2017

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20 March 2017

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The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

20 March 2017

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Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling

20 March 2017

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

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Shape complementarity at protein/protein interfaces

20 March 2017

1 reference

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The interpretation of protein structures: Estimation of static accessibility

20 March 2017

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

20 March 2017

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L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor

20 March 2017

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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

20 March 2017

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7 April 2017

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Curling of flap tips in HIV-1 protease as a mechanism for substrate entry and tolerance of drug resistance

7 April 2017

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Human immunodeficiency virus type-1 protease inhibitors: therapeutic successes and failures, suppression and resistance

29 September 2017

1 reference

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Validation of protein crystal structures

29 September 2017

1 reference

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Structural and biochemical studies of retroviral proteases

29 September 2017

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Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database

29 September 2017

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Resistance to human immunodeficiency virus type 1 protease inhibitors.

29 September 2017

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Genotypic Changes in Human Immunodeficiency Virus Type 1 Associated with Loss of Suppression of Plasma Viral RNA Levels in Subjects Treated with Ritonavir (Norvir) Monotherapy

29 September 2017

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Analysis of the Assembly Function of the Human Immunodeficiency Virus Type 1 Gag Protein Nucleocapsid Domain

29 September 2017

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Structural mechanisms of HIV drug resistance

29 September 2017

1 reference

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Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method

29 September 2017

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Where freedom is given, liberties are taken

29 September 2017

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Development of drug resistance to HIV-1 protease inhibitors

29 September 2017

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Structure-based inhibitors of HIV-1 protease

29 September 2017

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Subsite preferences of retroviral proteinases

29 September 2017

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Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

29 September 2017

HIV-Protease Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Kinetic Properties of Saquinavir-Resistant Mutants of Human Immunodeficiency Virus Type 1 Protease and Their Implications in Drug Resistance in Vivo

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Human immunodeficiency virus type 1 protease inhibitors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Fidelity of HIV-1 reverse transcriptase copying RNA in vitro

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

The accuracy of reverse transcriptase from HIV-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Activity of a ritonavir plus saquinavir-containing regimen in patients with virologic evidence of indinavir or ritonavir failure

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Resistance to HIV Protease Inhibitors: A Comparison of Enzyme Inhibition and Antiviral Potency

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Kinetic characterization of human immunodeficiency virus type-1 protease-resistant variants

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

Large scale purification and refolding of HIV-1 protease from Escherichia coli inclusion bodies.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140781

[AIDS: new FDA approved agents]

27 November 2018

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

The Regulation of Sequential Processing of HIV-1 Gag by the Viral Protease

1 reference

12 December 2020

Recent developments in HIV protease inhibitor therapy

1 reference

12 December 2020

10.1128/JVI.77.2.1306-1315.2003

Identifiers

DOI

1 reference

6 July 2017

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6 July 2017

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