Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography (Q27640105)

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Ciarán N Cronin

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Duncan E McRee

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Christian G Nelson

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Nikola P Pavletich

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Joe Rogers

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Bi-Ching Sang

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Daniel N Scheibe

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Ronald V Swanson

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Devon A Thompson

Protein kinases--the major drug targets of the twenty-first century?

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language of work or name

English

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publication date

December 2002

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published in

Structure

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volume

10

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issue

12

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page(s)

1659-67

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B61 is a ligand for the ECK receptor protein-tyrosine kinase

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Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase

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The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

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Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

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Overexpression of the EphA2 tyrosine kinase in prostate cancer.

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Molecular classification of cutaneous malignant melanoma by gene expression profiling

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Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

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EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).

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Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer

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Biochemical signals and biological responses elicited by the focal adhesion kinase

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The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

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Signaling through focal adhesion kinase

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Requirement for focal adhesion kinase in tumor cell adhesion

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Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia.

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cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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Mitotic kinases as regulators of cell division and its checkpoints

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

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Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

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Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

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Design of high-throughput methods of protein production for structural biology

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High-throughput protein crystallization

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Active and inactive protein kinases: structural basis for regulation

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The conformational plasticity of protein kinases

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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Structural basis of cyclin-dependent kinase activation by phosphorylation

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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

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Structure of GSK3beta reveals a primed phosphorylation mechanism

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Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

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Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

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CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

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Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

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Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12467573

1 reference

Consolidated OpenCitations Corpus – April 2017