The structural basis for the recognition of diverse receptor sequences by TRAF2 (Q27619945)

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Y C Park

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M Kreishman

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H Wu

Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation

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publication date

September 1999

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published in

Molecular Cell

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volume

4

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issue

3

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page(s)

321-30

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cites work

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CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase

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4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB

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Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death

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Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

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Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily

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Localization of the major NF-kappaB-activating site and the sole TRAF3 binding site of LMP-1 defines two distinct signaling motifs

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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TRAF6 is a signal transducer for interleukin-1

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TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation

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Involvement of CRAF1, a relative of TRAF, in CD40 signaling

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FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

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Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif

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Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

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CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

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TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

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The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein

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Association of the p75 neurotrophin receptor with TRAF6

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Assembly and regulation of the CD40 receptor complex in human B cells

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Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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An induced proximity model for caspase-8 activation.

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TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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ASK1 is essential for JNK/SAPK activation by TRAF2

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Processing of X-ray diffraction data collected in oscillation mode

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Structural basis for self-association and receptor recognition of human TRAF2

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CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization

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7 January 2021

Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma

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Combining evolutionary information and neural networks to predict protein secondary structure

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A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

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7 January 2021

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction

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7 January 2021

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

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The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death

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RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death

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A survey of left-handed polyproline II helices

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Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

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Signal transduction by receptors with tyrosine kinase activity

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Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB

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Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

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Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

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