Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism (Q27618148)

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7 December 2019

title

Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism (English)

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7 December 2019

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1

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7 December 2019

author name string

J Tang

2

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7 December 2019

H Schmidt

3

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M Stahl

4

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J D Clark

5

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J Seehra

6

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W S Somers

7

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language of work or name

English

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publication date

1 April 1999

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7 December 2019

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volume

97

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issue

3

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7 December 2019

page(s)

349-360

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

7 December 2019

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A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2 )-dependent translocation domain with homology to PKC and GAP

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Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes

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The growing phospholipase A2 superfamily of signal transduction enzymes

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Relationships among serine hydrolases: evidence for a common structural motif in triacylglyceride lipases and esterases

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Penicillin acylase has a single-amino-acid catalytic centre

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Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

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Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen

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C2 domain conformational changes in phospholipase C-delta 1

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Processive interfacial catalysis by mammalian 85-kilodalton phospholipase A2 enzymes on product-containing vesicles: application to the determination of substrate preferences

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Multiple enzymatic activities of the human cytosolic 85-kDa phospholipase A2: hydrolytic reactions and acyl transfer to glycerol

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Properties and regulation of cytosolic phospholipase A2.

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Anionic phospholipids stimulate an arachidonoyl-hydrolyzing phospholipase A2 from macrophages and reduce the calcium requirement for activity

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Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid

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cPLA2 is phosphorylated and activated by MAP kinase

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Catalytic properties of class A β-lactamases: efficiency and diversity

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Group IV Cytosolic Phospholipase A2 Binds with High Affinity and Specificity to Phosphatidylinositol 4,5-Bisphosphate Resulting in Dramatic Increases in Activity

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Location of the membrane-docking face on the Ca2 -activated C2 domain of cytosolic phospholipase A2

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7 January 2021

Independent Folding and Ligand Specificity of the C2 Calciumdependent Lipid Binding Domain of Cytosolic Phospholipase A2

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Leukotrienes in the pathogenesis of asthma

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Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2

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7 January 2021

Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine

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Identifiers

DOI

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7 December 2019

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