Nitrogen permease regulating protein NPR2 YEL062W (Q27552800)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P39923

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

IPI

molecular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

1 reference

9 May 2019

ND

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

1 reference

9 May 2019

vacuolar membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

1 reference

9 May 2019

GATOR1 complex

1 reference

16 July 2018

Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

extrinsic component of fungal-type vacuolar membrane

1 reference

16 July 2018

A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

vacuole

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

1 reference

9 May 2019

Seh1-associated complex

1 reference

9 May 2019

A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

extrinsic component of fungal-type vacuolar membrane

positive regulation of cellular response to amino acid starvation

biological process

1 reference

9 May 2019

A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

proline transport

1 reference

9 May 2019

A second nitrogen permease regulator in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

1 reference

16 July 2018

positive regulation of autophagy

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

2 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

16 July 2018

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

negative regulation of TOR signaling

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

16 July 2018

A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

16 July 2018

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

16 July 2018

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

16 July 2018

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

cellular response to nitrogen starvation

1 reference

16 July 2018

Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

protein transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

1 reference

9 May 2019

regulation of autophagosome assembly

1 reference

16 July 2018

Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

urea transport

1 reference

9 May 2019

A second nitrogen permease regulator in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39923&geneProductId=UniProtKB:P39923

1 reference

16 July 2018

positive regulation of peptidyl-serine phosphorylation

1 reference

9 May 2019

The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

cellular response to nitrogen starvation

positive regulation of autophagy

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

9 May 2019

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

negative regulation of TOR signaling

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

14 February 2019

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

14 February 2019

A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

14 February 2019

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

14 February 2019

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

cellular response to amino acid starvation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

negative regulation of TOR signaling

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

negative regulation of TORC1 signaling

A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

9 May 2019

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

9 May 2019

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

9 May 2019

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

9 May 2019

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39923

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference