Hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 YLR450W (Q27551371)

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, N-terminal

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Sterol-sensing domain, protein family

1 reference

inferred from protein domain or family

HMG-CoA reductase, N-terminal domain, protein family

1 reference

inferred from protein domain or family

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

1 reference

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

NADP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

8 April 2019

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

4 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

ISA

16 July 2018

Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

16 July 2018

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

5 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

ISA

14 January 2019

Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

14 January 2019

14 January 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

cell component

peroxisomal membrane

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

endoplasmic reticulum membrane

IDA

proteasome complex

IPI

1 reference

9 May 2019

Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

IPI

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

1 reference

7 November 2018

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

9 May 2019

9 May 2019

Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

IDA

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

integral component of membrane

Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis

4 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

ISM

14 January 2019

Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

14 January 2019

nuclear periphery

HDA

1 reference

9 May 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

coenzyme A metabolic process

HDA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

steroid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12684

1 reference

9 May 2019

sterol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12684&geneProductId=UniProtKB:P12684

1 reference

16 July 2018

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

has part(s)

1 reference

HMG-CoA reductase, N-terminal domain

1 reference

Sterol-sensing domain

1 reference