Hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 YML075C (Q27550779)

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily

1 reference

Hydroxymethylglutaryl-CoA reductase, N-terminal

1 reference

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Sterol-sensing domain, protein family

1 reference

inferred from protein domain or family

HMG-CoA reductase, N-terminal domain, protein family

1 reference

inferred from protein domain or family

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family

1 reference

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

27 March 2018

Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

27 March 2018

27 March 2018

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

NADP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

14 February 2019

hydroxymethylglutaryl-CoA reductase (NADPH) activity

Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

9 May 2019

Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

9 May 2019

9 May 2019

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

cell component

peroxisomal membrane

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

nuclear envelope

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

endoplasmic reticulum membrane

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

9 May 2019

9 May 2019

Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

integral component of membrane

Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis

4 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

ISM

14 January 2019

Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

14 January 2019

nuclear periphery

coenzyme A metabolic process

HDA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

steroid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

ergosterol biosynthetic process

1 reference

27 March 2018

Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

1 reference

9 May 2019

sterol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12683&geneProductId=UniProtKB:P12683

1 reference

27 March 2018

isopentenyl diphosphate biosynthetic process, mevalonate pathway

IC

1 reference

9 May 2019

Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12683

ergosterol biosynthetic process

IC

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site

has part(s)

1 reference

HMG-CoA reductase, N-terminal domain

1 reference

Sterol-sensing domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference