Phosphatidylinositol kinase-related protein kinase TOR1 YJR066W (Q27549557)

serine/threonine-protein kinase TOR

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

1 reference

Armadillo-like helical

1 reference

Armadillo-type fold

1 reference

FKBP12-rapamycin binding domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Phosphatidylinositol 3-/4-kinase, catalytic domain, protein family

1 reference

PIK-related kinase, FAT family

1 reference

FKBP12-rapamycin binding domain, protein family

1 reference

PIK-related kinase family

1 reference

FATC domain, protein family

1 reference

Domain of unknown function DUF3385, target of rapamycin protein family

1 reference

Phosphatidylinositol 3/4-kinase, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

protein binding

6 references

14 February 2019

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

A global protein kinase and phosphatase interaction network in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

Superoxide anions regulate TORC1 and its ability to bind Fpr1:rapamycin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

protein kinase activity

1 reference

14 February 2019

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

protein-containing complex binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

27 February 2018

27 February 2018

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

14 February 2019

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

fungal-type vacuole membrane

cell component

4 references

10 September 2018

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

10 September 2018

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

10 September 2018

TOR1 and TOR2 have distinct locations in live cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

10 September 2018

The Vam6 GEF controls TORC1 by activating the EGO complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

vacuole

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

nucleus

1 reference

27 February 2018

Nutrient regulates Tor1 nuclear localization and association with rDNA promoter.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

TORC1 complex

1 reference

27 February 2018

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

Golgi membrane

1 reference

14 February 2019

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

vacuolar membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

extrinsic component of cytoplasmic side of plasma membrane

1 reference

14 February 2019

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

endosome membrane

1 reference

14 February 2019

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

TORC1 complex

TORC2 complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

fungal-type vacuole membrane

TOR1 and TOR2 have distinct locations in live cells

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

The Vam6 GEF controls TORC1 by activating the EGO complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

HDA

biological process

TOR signaling

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

14 February 2019

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

IC

ribosome biogenesis

1 reference

14 February 2019

Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

nucleolar large rRNA transcription by RNA polymerase I

1 reference

14 February 2019

Nutrient regulates Tor1 nuclear localization and association with rDNA promoter.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

regulation of sphingolipid biosynthetic process

1 reference

14 February 2019

TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

regulation of cell growth

1 reference

14 February 2019

Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

negative regulation of autophagy

1 reference

27 February 2018

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

peptidyl-serine phosphorylation

1 reference

14 February 2019

TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

fungal-type cell wall organization

1 reference

14 February 2019

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

translational initiation

1 reference

14 February 2019

TOR controls translation initiation and early G1 progression in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

mitochondria-nucleus signaling pathway

1 reference

14 February 2019

The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

1 reference

14 February 2019

regulation of cell cycle

1 reference

14 February 2019

TOR controls translation initiation and early G1 progression in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

cellular response to DNA damage stimulus

1 reference

14 February 2019

TOR signaling is a determinant of cell survival in response to DNA damage.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

regulation of snRNA pseudouridine synthesis

1 reference

14 February 2019

The TOR signaling pathway regulates starvation-induced pseudouridylation of yeast U2 snRNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

cellular response to oxidative stress

1 reference

14 February 2019

Slm35 links mitochondrial stress response and longevity through TOR signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

cellular response to heat

1 reference

14 February 2019

Slm35 links mitochondrial stress response and longevity through TOR signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

meiosis

1 reference

14 February 2019

Target of rapamycin proteins and their kinase activities are required for meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35169&geneProductId=UniProtKB:P35169

1 reference

27 February 2018

negative regulation of protein kinase activity by regulation of protein phosphorylation

1 reference

14 February 2019

Nitrogen availability and TOR regulate the Snf1 protein kinase in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

negative regulation of autophagy

negative regulation of macroautophagy

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

TORC1 signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35169

has part(s)

PIK-related kinase, FAT

1 reference

Domain of unknown function DUF3385, target of rapamycin protein

1 reference

FATC domain

1 reference

Phosphatidylinositol 3-/4-kinase, catalytic domain

1 reference

PIK-related kinase

1 reference

Phosphatidylinositol 3/4-kinase, conserved site

1 reference

FKBP12-rapamycin binding domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference