Chromatin-silencing transcriptional regulator TUP1 YCR084C (Q27548094)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16649

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16649

Transcriptional repressor Tup1, N-terminal domain, protein family

1 reference

WD40 repeat, protein family

1 reference

WD40 repeat, conserved site, protein family

1 reference

G-protein beta WD-40 repeat, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

phosphatidylinositol-3,5-bisphosphate binding

1 reference

9 May 2019

Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

histone binding

1 reference

10 September 2018

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16649&geneProductId=UniProtKB:P16649

protein binding

7 references

9 May 2019

An in vivo map of the yeast protein interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Ssn6-Tup1 interacts with class I histone deacetylases required for repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

transcription corepressor activity

transcription corepressor activity

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

transcription repressor complex

IBA

cell component

1 reference

9 May 2019

A complex composed of tup1 and ssn6 represses transcription in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

3 references

9 May 2019

IEA

9 May 2019

Ssn6-Tup1 is a general repressor of transcription in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

negative regulation of transcription by RNA polymerase II

IBA

biological process

3 references

10 September 2018

The Tup1-Ssn6 general repressor is involved in repression of IME1 encoding a transcriptional activator of meiosis in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16649&geneProductId=UniProtKB:P16649

10 September 2018

Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16649&geneProductId=UniProtKB:P16649

10 September 2018

A yeast protein with homology to the beta-subunit of G proteins is involved in control of heme-regulated and catabolite-repressed genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16649&geneProductId=UniProtKB:P16649

regulation of invasive growth in response to glucose limitation

1 reference

9 May 2019

Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16649&geneProductId=UniProtKB:P16649

1 reference

27 March 2018

IEA

histone exchange

1 reference

9 May 2019

The Tup1 corepressor directs Htz1 deposition at a specific promoter nucleosome marking the GAL1 gene for rapid activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

carbon catabolite repression of transcription from RNA polymerase II promoter by glucose

1 reference

9 May 2019

Identification of cis-acting elements in the SUC2 promoter of Saccharomyces cerevisiae required for activation of transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

regulation of response to DNA damage stimulus

1 reference

9 May 2019

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16649&geneProductId=UniProtKB:P16649

1 reference

27 March 2018

positive regulation of transcription by RNA polymerase II

IEA

1 reference

9 May 2019

Yeast Cyc8p and Tup1p proteins function as coactivators for transcription of Stp1/2p-dependent amino acid transporter genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

negative regulation of transcription by RNA polymerase II

The Tup1-Ssn6 general repressor is involved in repression of IME1 encoding a transcriptional activator of meiosis in Saccharomyces cerevisiae

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

A yeast protein with homology to the beta-subunit of G proteins is involved in control of heme-regulated and catabolite-repressed genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16649