protein tyrosine kinase 2 (Q2744706)

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mammalian protein found in Homo sapiens
  • Protein-tyrosine kinase 2
  • focal adhesion kinase-related nonkinase
  • focal adhesion kinase isoform FAK-Del33
  • FRNK
  • p125FAK
  • PTK2
  • PPP1R71
  • FADK 1
  • FAK-related non-kinase polypeptide
  • PTK2 protein tyrosine kinase 2
  • focal adhesion kinase 1
  • pp125FAK
  • protein phosphatase 1 regulatory subunit 71
  • Focal adhesion kinase 1
edit
Language Label Description Also known as
English
protein tyrosine kinase 2
mammalian protein found in Homo sapiens
  • Protein-tyrosine kinase 2
  • focal adhesion kinase-related nonkinase
  • focal adhesion kinase isoform FAK-Del33
  • FRNK
  • p125FAK
  • PTK2
  • PPP1R71
  • FADK 1
  • FAK-related non-kinase polypeptide
  • PTK2 protein tyrosine kinase 2
  • focal adhesion kinase 1
  • pp125FAK
  • protein phosphatase 1 regulatory subunit 71
  • Focal adhesion kinase 1

Statements

part of
molecular function
protein binding
determination method or standard
IPI
38 references
retrieved
8 April 2019
stated in
A novel Cas family member, HEPL, regulates FAK and cell spreading
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Protein complexes involving alpha v beta 3 integrins, nonmuscle myosin heavy chain-A, and focal adhesion kinase from in thrombospondin-treated smooth muscle cells
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2)
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Retracted: Epithelial Membrane Protein-2 Promotes Endometrial Tumor Formation through Activation of FAK and Src
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of T24 human bladder carcinoma cell migration by RNA interference suppressing the expression of HD-PTP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of focal adhesion kinase through an interaction with β4 integrin contributes to tumorigenicity of colon cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
FAK promotes recruitment of talin to nascent adhesions to control cell motility
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proinvasion metastasis drivers in early-stage melanoma are oncogenes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of rapid oestrogen signalling in aggressive human breast cancers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of dystrophins and utrophins in platelet adhesion process
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IPI
protein tyrosine kinase activity
determination method or standard
EXP
IEA
ISS
TAS
8 references
retrieved
21 June 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
TAS
retrieved
21 June 2018
stated in
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
ISS
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
21 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
21 June 2018
stated in
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
EXP
retrieved
21 June 2018
stated in
Focal adhesion kinase regulation of N-WASP subcellular localization and function
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
EXP
retrieved
21 June 2018
stated in
Alternative splicing controls the mechanisms of FAK autophosphorylation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
EXP
cell component
focal adhesion
determination method or standard
IDA
IEA
6 references
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
16 July 2018
stated in
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IDA
retrieved
16 July 2018
stated in
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IDA
retrieved
16 July 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05397&geneProductId=UniProtKB:Q05397
determination method or standard
IDA
focal adhesion
determination method or standard
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IEA
retrieved
8 April 2019
stated in
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IDA
retrieved
8 April 2019
stated in
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53
GOA
curator
UniProt
UniProt protein ID
Q05397
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05397
determination method or standard
IBA
biological process
Gene Atlas image
PBB GE PTK2 207821 s at fs.png
732 × 530; 12 KB
0 references
has part(s)

Identifiers

MeSH descriptor ID
D051417
subject named as
Focal Adhesion Kinase 1
0 references
RefSeq protein ID
Ensembl protein ID
PDB structure ID
 
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