Novel polyglutamine model uncouples proteotoxicity from aging (Q27333876)

1

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Amy L Lee

2

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Hannah G Fay

3

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Amelia A Gray

4

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Elise A Kikis

Creative Commons Attribution 4.0 International

5

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language of work or name

English

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publication date

2014

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published in

PLOS One

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volume

9

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issue

5

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page(s)

e96835

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copyright license

start time

9 May 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Identification of a tissue-selective heat shock response regulatory network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

A genetic screening strategy identifies novel regulators of the proteostasis network

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Widespread protein aggregation as an inherent part of aging in C. elegans

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Secondary Structure of Huntingtin Amino-Terminal Region

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

The genetics of Caenorhabditis elegans

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

21 March 2017

Conformational disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Opposing activities protect against age-onset proteotoxicity

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Regulation of organismal proteostasis by transcellular chaperone signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Protein Homeostasis in Models of Aging and Age-Related Conformational Disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Neurotoxic protein oligomerisation associated with polyglutamine diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

A cellular perspective on conformational disease: the role of genetic background and proteostasis networks

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Examining polyglutamine peptide length: a connection between collapsed conformations and increased aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases: exposed beta-sheet hypothesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Trinucleotide repeat length instability and age of onset in Huntington's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Deadly conformations--protein misfolding in prion disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4016013

Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail

2 June 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

The pathogenic agent in Drosophila models of 'polyglutamine' diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

Insulin signaling and the heat shock response modulate protein homeostasis in the Caenorhabditis elegans intestine during infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371/JOURNAL.PONE.0096835

Polyglutamine protein aggregates are dynamic

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24817148

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24817148

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modeling polyglutamine pathogenesis in C. elegans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24817148