Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models (Q27322622)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23754957 AND SRC:MED&resulttype=core&format=json

2 March 2020

title

Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models (English)

1 reference

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Achaete-scute family bHLH transcription factor 1a

2 March 2020

main subject

Danio rerio

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1 reference

GOA release 2020-03-11

author

Barry H Paw

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23754957 AND SRC:MED&resulttype=core&format=json

2 March 2020

Rodney A. Stewart

5

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2 March 2020

author name string

Desheng Pei

1

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2 March 2020

William Luther

2

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2 March 2020

Wenchao Wang

3

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2 March 2020

Rani E George

6

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2 March 2020

language of work or name

English

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publication date

6 June 2013

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2 March 2020

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2 March 2020

volume

9

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issue

6

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2 March 2020

page(s)

e1003533

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Creative Commons Attribution 4.0 International

2 March 2020

copyright license

start time

6 June 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism

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Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome

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BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

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Essential role of Gata transcription factors in sympathetic neuron development

21 March 2017

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Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system

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The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

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Studying peripheral sympathetic nervous system development and neuroblastoma in zebrafish

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Neuroblastoma phox2b variants stimulate proliferation and dedifferentiation of immature sympathetic neurons

28 September 2017

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MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development

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Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons

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PHOX2B genotype allows for prediction of tumor risk in congenital central hypoventilation syndrome

28 September 2017

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tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

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The Phox2B homeobox gene is mutated in sporadic neuroblastomas

28 September 2017

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Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

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Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a

28 September 2017

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Expression of HAND gene products may be sufficient for the differentiation of avian neural crest-derived cells into catecholaminergic neurons in culture

28 September 2017

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Cellular and molecular determinants of sympathetic neuron development

28 September 2017

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MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity

28 September 2017

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PHOX2B mutations and polyalanine expansions correlate with the severity of the respiratory phenotype and associated symptoms in both congenital and late onset Central Hypoventilation syndrome

28 September 2017

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Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system

31 May 2018

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Neuroblast mitosis in dissociated culture: regulation and relationship to differentiation

31 May 2018

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Significance of MYCN amplification in international neuroblastoma staging system stage 1 and 2 neuroblastoma: a report from the International Neuroblastoma Risk Group database

31 May 2018

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PHOX2B analysis in non-syndromic neuroblastoma cases shows novel mutations and genotype-phenotype associations.

21 January 2018

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Germline PHOX2B mutation in hereditary neuroblastoma

21 January 2018

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The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons

21 January 2018

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Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype

21 January 2018

1 reference

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Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function

21 January 2018

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Variable human phenotype associated with novel deletions of the PHOX2B gene

21 January 2018

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Prevalence and functional consequence of PHOX2B mutations in neuroblastoma.

21 January 2018

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Distinct pathogenetic mechanisms for PHOX2B associated polyalanine expansions and frameshift mutations in congenital central hypoventilation syndrome

21 January 2018

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Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent

21 January 2018

1 reference

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Hu neuronal proteins are expressed in proliferating neurogenic cells.

21 January 2018

1 reference

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Interaction of Mash1 and Phox2b in sympathetic neuron development

21 January 2018

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https://api.crossref.org/works/10.1371/JOURNAL.PGEN.1003533

Progenitor cell maintenance and neurogenesis in sympathetic ganglia involves Notch signaling

21 January 2018

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Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction

21 January 2018

1 reference

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PHOX2B germline and somatic mutations in late-onset central hypoventilation syndrome

21 January 2018

1 reference

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Haploinsufficiency for Phox2b in mice causes dilated pupils and atrophy of the ciliary ganglion: mechanistic insights into human congenital central hypoventilation syndrome.

21 January 2018

1 reference

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Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates.

21 January 2018

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The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification.

27 November 2018

1 reference

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The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives

27 November 2018

1 reference

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The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons.

27 November 2018

1 reference

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Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation.

27 November 2018

1 reference

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The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system

27 November 2018

1 reference

12 December 2020

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

1 reference

12 December 2020

The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity

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12 December 2020

Idiopathic congenital central hypoventilation syndrome: Analysis of genes pertinent to early autonomic nervous system embryologic development and identification of mutations in PHOX2b

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1003533

Identifiers

DOI

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release_d4whar2pn5gnre65vpisxuoh6a

2 March 2020

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Fatcat

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24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23754957 AND SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

23754957

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23754957 AND SRC:MED&resulttype=core&format=json