Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model (Q27321389)

1

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Jenny K Gustafsson

2

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Karolina E Sjöberg

3

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Joel Petersson

4

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Lena Holm

5

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Henrik Sjövall

Creative Commons Attribution 4.0 International

6

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language of work or name

English

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publication date

2010

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published in

PLOS One

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volume

5

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issue

8

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page(s)

e12238

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copyright license

start time

18 August 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Colorectal cancer in mice genetically deficient in the mucin Muc2

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Intestinal mucosal barrier function in health and disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Gel-forming mucins appeared early in metazoan evolution.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Small-scale analysis of O-linked oligosaccharides from glycoproteins and mucins separated by gel electrophoresis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Clinicopathologic study of dextran sulfate sodium experimental murine colitis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Reduced mucin sulfonation and impaired intestinal barrier function in the hyposulfataemic NaS1 null mouse.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Acid transport through channels in the mucous layer of rat stomach

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2923597

Colonic ulceration in young rats fed degraded carrageenan

28 November 2018

1 reference

12 December 2020

Animal models of inflammatory bowel disease

1 reference

12 December 2020

Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4( ) -cell depleted, athymic and NK-cell depleted SCID mice

1 reference

12 December 2020

Histological analysis of murine colitis induced by dextran sulfate sodium of different molecular weights

1 reference

12 December 2020

The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo

1 reference

12 December 2020

A new role for cathelicidin in ulcerative colitis in mice

1 reference

12 December 2020

Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice

1 reference

12 December 2020

Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0012238

Identifiers

DOI

1 reference

ADS bibcode

2010PLoSO...512238J

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1 reference

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PubMed publication ID

20805871

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