FVIII inhibitors: pathogenesis and avoidance (Q27027224)

Crossref

language of work or name

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26 March 2015

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125

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issue

13

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page(s)

2045-51

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The danger theory: 20 years later

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Increased prevalence of inhibitors in Hispanic patients with severe haemophilia A enrolled in the Universal Data Collection database

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Downregulation of CD40 Signal and Induction of TGF-β by Phosphatidylinositol Mediates Reduction in Immunogenicity Against Recombinant Human Factor VIII

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28 September 2017

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Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice

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Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice

28 September 2017

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High-dose factor VIII inhibits factor VIII-specific memory B cells in hemophilia A with factor VIII inhibitors

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Preventing restimulation of memory B cells in hemophilia A: a potential new strategy for the treatment of antibody-dependent immune disorders

31 May 2018

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31 May 2018

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In silico calculated affinity of FVIII-derived peptides for HLA class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 gene

31 May 2018

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Long-term anti-FVIII antibody response in Bethesda-negative haemophilia A patients receiving continuous replacement therapy

28 November 2018

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Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia A.

28 November 2018

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Impact of HLA alleles and cytokine polymorphisms on inhibitors development in children with severe haemophilia A.

28 November 2018

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Product-dependent anti-factor VIII antibodies

28 November 2018

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Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study

28 November 2018

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Factor VIII products and inhibitor development in severe hemophilia A.

28 November 2018

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Distinct characteristics of antibody responses against factor VIII in healthy individuals and in different cohorts of hemophilia A patients.

28 November 2018

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Immune regulatory gene polymorphisms as predisposing risk factors for the development of factor VIII inhibitors in Indian severe haemophilia A patients

28 November 2018

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Impact of polymorphisms in genes involved in autoimmune disease on inhibitor development in Chinese patients with haemophilia A

28 November 2018

1 reference

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Immunoprotective effect of von Willebrand factor towards therapeutic factor VIII in experimental haemophilia A.

28 November 2018

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Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain

28 November 2018

1 reference

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T cell–independent restimulation of FVIII-specific murine memory B cells is facilitated by dendritic cells together with toll-like receptor 7 agonist

28 November 2018

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Analysis of cytokine genes polymorphism as markers for inhibitor development in haemophilia A.

28 November 2018

1 reference

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New early prophylaxis regimen that avoids immunological danger signals can reduce FVIII inhibitor development

28 November 2018

1 reference

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Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A.

28 November 2018

1 reference

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Intensive peri-operative use of factor VIII and the Arg593-->Cys mutation are risk factors for inhibitor development in mild/moderate hemophilia A.

28 November 2018

1 reference

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Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4416939

Treatment characteristics and the risk of inhibitor development: a multicenter cohort study among previously untreated patients with severe hemophilia A.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4416939

28 November 2018

1 reference

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Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A.

28 November 2018

1 reference

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VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors.

28 November 2018

1 reference

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Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A.

28 November 2018

1 reference

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Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4416939

The prevalence of proteolytic antibodies against factor VIII in hemophilia A.

28 November 2018

1 reference

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Epitope mapping of factor VIII inhibitor antibodies of Chinese origin

28 November 2018

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The Malmö International Brother Study (MIBS): further support for genetic predisposition to inhibitor development in hemophilia patients

28 November 2018

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Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A.

28 November 2018

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Immune tolerance induction and the treatment of hemophilia. Malmö protocol update

28 November 2018

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The Malmö model for immune tolerance induction: impact of previous treatment on outcome

28 November 2018

1 reference

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Prevention and treatment of factor VIII inhibitors in murine hemophilia A.

28 November 2018

1 reference

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Inhibitors occur more frequently in African-American and Latino haemophiliacs

28 November 2018

1 reference

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Blockade of CD40/CD40 ligand interactions prevents induction of factor VIII inhibitors in hemophilic mice but does not induce lasting immune tolerance

28 November 2018

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12 December 2020

A higher than expected incidence of factor VIII inhibitors in multitransfused haemophilia A patients treated with an intermediate purity pasteurized factor VIII concentrate

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12 December 2020

Expansion of CD4 CD25 regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis

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12 December 2020

CD101 surface expression discriminates potency among murine FoxP3 regulatory T cells

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12 December 2020

The Malmö International Brother Study (MIBS). Genetic defects and inhibitor development in siblings with severe hemophilia A

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12 December 2020

Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice

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12 December 2020

Methotrexate reduces antibody responses to recombinant human alpha-galactosidase A therapy in a mouse model of Fabry disease

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release_d7567rylz5bxtbldqomlnh3x24

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1 reference

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PubMed publication ID

25712994

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