On the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP Peptides (Q27022467)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

7 June 2020

Giuseppe Pappalardo

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Alessandro Sinopoli

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

1 reference

2015

1 reference

Journal of Diabetes Research

25 October 2015

10 references

13 March 2019

14 March 2019

24 March 2019

5 August 2019

7 October 2019

10 October 2019

17 November 2019

20 November 2019

27 January 2021

4 February 2021

12 references

13 March 2019

14 March 2019

24 March 2019

5 August 2019

7 October 2019

10 October 2019

17 November 2019

20 November 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

7 June 2020

27 January 2021

4 February 2021

2015

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

918573

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

7 June 2020

copyright license

10 references

13 March 2019

14 March 2019

24 March 2019

5 August 2019

7 October 2019

10 October 2019

17 November 2019

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on focus list of Wikimedia project

4 February 2021

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copyrighted

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Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Fiber-dependent amyloid formation as catalysis of an existing reaction pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Membrane interaction of islet amyloid polypeptide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Inhibition of insulin secretion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Zinc, the pancreas, and diabetes: insights from rodent studies and future directions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Raft lipids as common components of human extracellular amyloid fibrils

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Amyloid-beta metal interaction and metal chelation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

The metallobiology of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Transition metal chelator therapy--a potential treatment for Alzheimer's disease?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Mitochondrial function in normal and diabetic beta-cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Islet amyloid and type 2 diabetes mellitus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Induction of apoptosis by human amylin in RINm5F islet beta-cells is associated with enhanced expression of p53 and p21WAF1/CIP1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Pancreatic pathology in non-insulin dependent diabetes (NIDDM).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Elemental composition of secretory granules in pancreatic islets of Langerhans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Newly identified pancreatic protein islet amyloid polypeptide. What is its relationship to diabetes?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Copper transport: an overview

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Clinical Pharmacokinetics of Rifampicin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

A membrane-bound antiparallel dimer of rat islet amyloid polypeptide

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Role of zinc in human islet amyloid polypeptide aggregation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Aggregation properties of the peptide fragments derived from the 17-29 region of the human and rat IAPP: a comparative study with two PEG-conjugated variants of the human sequence

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

A novel assay in vitro of human islet amyloid polypeptide amyloidogenesis and effects of insulin secretory vesicle peptides on amyloid formation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Zinc, Insulin and Diabetes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Amylin, Calcitonin Gene-Related Peptide, Calcitonin, and Adrenomedullin: A Peptide Superfamily

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Pancreatic islet amyloid and elevated proinsulin secretion in familial maturity-onset diabetes.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: is there a critical amyloidogenic domain in human IAPP?

31 May 2018

1 reference

The parallel superpleated beta-structure as a model for amyloid fibrils of human amylin

21 January 2018

1 reference

Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts

21 January 2018

1 reference

Cholesterol regulates assembly of human islet amyloid polypeptide on model membranes

21 January 2018

1 reference

Interaction of hIAPP with model raft membranes and pancreatic beta-cells: cytotoxicity of hIAPP oligomers

21 January 2018

1 reference

The role of His-18 in amyloid formation by human islet amyloid polypeptide

21 January 2018

1 reference

pH dependence of amylin fibrillization

21 January 2018

1 reference

Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principles

21 January 2018

1 reference

Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus

21 January 2018

1 reference

Interactions of copper with glycated proteins: possible involvement in the etiology of diabetic neuropathy

21 January 2018

1 reference

The amylin peptide implicated in type 2 diabetes stimulates copper-mediated carbonyl group and ascorbate radical formation.

21 January 2018

1 reference

Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.

21 January 2018

1 reference

Copper(II) inhibits the formation of amylin amyloid in vitro

21 January 2018

1 reference

Copper(II) complexes of rat amylin fragments.

21 January 2018

1 reference

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

21 January 2018

1 reference

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

21 January 2018

1 reference

Amyloid oligomers in diabetic and nondiabetic human pancreas

21 January 2018

1 reference

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

21 January 2018

1 reference

Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

21 January 2018

1 reference

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

21 January 2018

1 reference

Lipid membranes modulate the structure of islet amyloid polypeptide.

21 January 2018

1 reference

Phospholipid catalysis of diabetic amyloid assembly

21 January 2018

1 reference

Synergistic action of polyanionic and non-polar cofactors in fibrillation of human islet amyloid polypeptide.

21 January 2018

1 reference

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

21 January 2018

1 reference

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

21 January 2018

1 reference

Fibril formation and toxicity of the non-amyloidogenic rat amylin peptide.

21 January 2018

1 reference

Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide

21 January 2018

1 reference

Amyloidogenic propensities and conformational properties of ProIAPP and IAPP in the presence of lipid bilayer membranes.

21 January 2018

1 reference

Seeding specificity in amyloid growth induced by heterologous fibrils

21 January 2018

1 reference

Beta-amyloid monomers are neuroprotective.

21 January 2018

1 reference

Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition.

21 January 2018

1 reference

Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity.

21 January 2018

1 reference

Cross-amyloid interaction of Aβ and IAPP at lipid membranes

21 January 2018

1 reference

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

21 January 2018

1 reference

Conserved and Cooperative Assembly of Membrane-Bound α-Helical States of Islet Amyloid Polypeptide†

21 January 2018

1 reference

Molecular and cytotoxic properties of hIAPP17–29 and rIAPP17–29 fragments: A comparative study with the respective full-length parent polypeptides

21 January 2018

1 reference

Copper-mediated formation of hydrogen peroxide from the amylin peptide: A novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?

21 January 2018

1 reference

Actions of amylin on subfornical organ neurons and on drinking behavior in rats

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4637107

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

28 November 2018

1 reference

12 December 2020

Influence of islet amyloid polypeptide and the 8-37 fragment of islet amyloid polypeptide on insulin release from perifused rat islets

1 reference

12 December 2020

Effect of pH and insulin on fibrillogenesis of islet amyloid polypeptide in vitro

1 reference

12 December 2020

Pore formation by the cytotoxic islet amyloid peptide amylin

1 reference

12 December 2020

Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction

1 reference

12 December 2020

Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro

1 reference

12 December 2020

Effects of beta cell granule components on human islet amyloid polypeptide fibril formation

1 reference

12 December 2020

Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers

1 reference

12 December 2020

Inhibitory effect of amylin (islet amyloid polypeptide) on insulin response to non-glucose stimuli. Study in perfused rat pancreas

1 reference

12 December 2020

The Human Islet Amyloid Polypeptide Forms Transient Membrane-Active Prefibrillar Assemblies†

1 reference

12 December 2020

Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells

1 reference

12 December 2020

Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species

1 reference

12 December 2020

Molecular mapping of the recognition interface between the islet amyloid polypeptide and insulin

1 reference

12 December 2020

Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils

1 reference

12 December 2020

Islet amyloid polypeptide inserts into phospholipid monolayers as monomer

1 reference

12 December 2020

A Single-Point Mutation Converts the Highly Amyloidogenic Human Islet Amyloid Polypeptide into a Potent Fibrillization Inhibitor

1 reference

12 December 2020

Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets

1 reference

12 December 2020

Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells

1 reference

12 December 2020

Fine structure of islets of Langerhans in insular amyloidosis

1 reference

12 December 2020

Identifiers

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

7 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26582441 AND SRC:MED&resulttype=core&format=json