Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer (Q27021391)

Han Choi

series ordinal

2

1 reference

Kyeung Joo

series ordinal

3

1 reference

Do-Hyun Nam

series ordinal

4

1 reference

International Journal of Molecular Sciences

language of work or name

1 reference

25 February 2015

9 references

3 April 2019

2 August 2019

28 September 2019

20 November 2019

18 December 2019

26 August 2020

23 January 2021

8 February 2021

9 references

3 April 2019

2 August 2019

28 September 2019

20 November 2019

18 December 2019

26 August 2020

23 January 2021

8 February 2021

16

1 reference

issue

3

1 reference

page(s)

4471-91

1 reference

Creative Commons Attribution

copyright license

8 references

3 April 2019

2 August 2019

28 September 2019

20 November 2019

18 December 2019

26 August 2020

23 January 2021

8 February 2021

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii

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The tyrosine kinase Syk regulates TPL2 activation signals

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ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

21 March 2017

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NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity

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The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2

21 March 2017

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Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

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Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

21 March 2017

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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

21 March 2017

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Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase

21 March 2017

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Cancer-related inflammation

21 March 2017

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NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

21 March 2017

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The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases

21 March 2017

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Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis

21 March 2017

1 reference

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Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice

21 March 2017

1 reference

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Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase

21 March 2017

1 reference

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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

21 March 2017

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21 March 2017

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TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis

21 March 2017

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Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

21 March 2017

1 reference

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TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

21 March 2017

1 reference

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Cot kinase activates tumor necrosis factor-alpha gene expression in a cyclosporin A-resistant manner

21 March 2017

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Cot kinase regulation of IL-2 production in Jurkat T cells

21 March 2017

1 reference

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ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

21 March 2017

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Transcriptional regulation by the MAP kinase signaling cascades

21 March 2017

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

21 March 2017

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Smoldering and polarized inflammation in the initiation and promotion of malignant disease

7 April 2017

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Tpl2 induces castration resistant prostate cancer progression and metastasis

7 April 2017

1 reference

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IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases

28 September 2017

1 reference

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TPL2 kinase regulates the inflammatory milieu of the myeloma niche

28 September 2017

1 reference

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Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions

28 September 2017

1 reference

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Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation

28 September 2017

1 reference

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Tpl2 inhibitors thwart endothelial cell function in angiogenesis and peritoneal dissemination

28 September 2017

1 reference

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Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma.

28 September 2017

1 reference

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TPL2 kinase is a suppressor of lung carcinogenesis

28 September 2017

1 reference

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Roles of versican in cancer biology--tumorigenesis, progression and metastasis

28 September 2017

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Molecular pathways: mitogen-activated protein kinase pathway mutations and drug resistance

28 September 2017

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Targeting monocytes/macrophages in the treatment of rheumatoid arthritis.

28 September 2017

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IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400

28 September 2017

1 reference

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Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis

28 September 2017

1 reference

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Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice

28 September 2017

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Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

28 September 2017

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Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.

28 September 2017

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Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases

28 September 2017

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Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration.

28 September 2017

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Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer

28 September 2017

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Tpl2 kinase signal transduction in inflammation and cancer.

28 September 2017

1 reference

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TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Cot/Tpl-2 protein kinase as a target for the treatment of inflammatory disease

28 September 2017

1 reference

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TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Overexpression of far upstream element binding proteins: a mechanism regulating proliferation and migration in liver cancer cells

28 September 2017

1 reference

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Expression of Toll-like receptor 4 in the prostate gland and its association with the severity of prostate cancer

28 September 2017

1 reference

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The versatile role of MSKs in transcriptional regulation.

28 September 2017

1 reference

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TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases

28 September 2017

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Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma.

28 September 2017

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Targeting protein kinases for the development of anti-inflammatory drugs

28 September 2017

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Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin

28 September 2017

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NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

28 September 2017

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Tpl-2/Cot and COX-2 in breast cancer.

28 September 2017

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The complexity of mitogen-activated protein kinases (MAPKs) made simple

28 September 2017

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The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases).

28 September 2017

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The RSK factors of activating the Ras/MAPK signaling cascade

28 September 2017

1 reference

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Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis

28 September 2017

1 reference

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Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.

28 September 2017

1 reference

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Endothelial cells enhance tumor cell invasion through a crosstalk mediated by CXC chemokine signaling

28 September 2017

1 reference

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Tumor necrosis factor-alpha promotes malignant pleural effusion

28 September 2017

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Cot, a novel kinase of histone H3, induces cellular transformation through up-regulation of c-fos transcriptional activity

28 September 2017

1 reference

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Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages

28 September 2017

1 reference

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Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway.

28 September 2017

1 reference

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The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells

28 September 2017

1 reference

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Regulation of gene transcription by mitogen-activated protein kinase signaling pathways.

28 September 2017

1 reference

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Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype

28 September 2017

1 reference

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Mechanisms of transcoelomic metastasis in ovarian cancer.

28 September 2017

1 reference

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

28 September 2017

1 reference

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Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

28 September 2017

1 reference

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MAPKAP kinases - MKs - two's company, three's a crowd

28 September 2017

1 reference

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MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alpha protein

28 September 2017

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Regulation of cellular functions by the ERK5 signalling pathway

28 September 2017

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PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

28 September 2017

1 reference

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Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

28 September 2017

1 reference

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Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

IkappaB kinase is an essential component of the Tpl2 signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Radical causes of cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

The role of TNF alpha and IL-1 in rheumatoid arthritis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

The role of oncogenic kinases in human cancer (Review).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: activation by provirus insertion.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator protein 1 induced by EGF.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Thrombin stimulates fibroblast chemotaxis and replication

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Identification of the cells expressing cot proto-oncogene mRNA.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals

31 May 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Cot/Tpl2 regulates IL-23 p19 expression in LPS-stimulated macrophages through ERK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Integrative tumor board: metastatic renal cell carcinoma: naturopathic medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Honokiol thwarts gastric tumor growth and peritoneal dissemination by inhibiting Tpl2 in an orthotopic model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Interleukin-17 induces AP-1 activity and cellular transformation via upregulation of tumor progression locus 2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

How well do angiogenesis inhibitors work? Biomarkers of response prove elusive.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment o

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Discovery of indazoles as inhibitors of Tpl2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Luteolin, a Novel Natural Inhibitor of Tumor Progression Locus 2 Serine/Threonine Kinase, Inhibits Tumor Necrosis Factor-α-Induced Cyclooxygenase-2 Expression in JB6 Mouse Epidermis Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394431

Cot/Tpl2 and PKCζ cooperate in the regulation of the transcriptional activity of NFATc2 through the phosphorylation of its amino-terminal domain☆

28 November 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS16034471

Anti-angiogenic activity of sesterterpenes; natural product inhibitors of FGF-2-induced angiogenesis

21 January 2018

1 reference

12 December 2020

p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells

1 reference

12 December 2020

Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB

1 reference

12 December 2020

Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis

1 reference

12 December 2020

Overexpression of the Tpl-2/Cot oncogene in human breast cancer

1 reference

12 December 2020

Gastric cancer originating from bone marrow-derived cells

1 reference

12 December 2020

Tumor Necrosis Factor α As a New Target for Renal Cell Carcinoma: Two Sequential Phase II Trials of Infliximab at Standard and High Dose

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS16034471

1 reference

1 reference

1 reference

PubMed publication ID

25723737

1 reference