The anti-addiction drug ibogaine and the heart: a delicate relation (Q27009689)

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29 February 2020

review article

1 reference

title

The anti-addiction drug ibogaine and the heart: a delicate relation (English)

1 reference

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29 February 2020

main subject

heterocyclic compound

1 reference

17 September 2019

1 reference

1

1 reference

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29 February 2020

Karlheinz Hilber

series ordinal

2

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29 February 2020

author name string

Xaver Koenig

series ordinal

1

1 reference

Karlheinz Hilber

series ordinal

2

1 reference

language of work or name

1 reference

29 January 2015

3 references

17 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25642835 AND SRC:MED&resulttype=core&format=json

29 February 2020

3 references

17 September 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25642835 AND SRC:MED&resulttype=core&format=json

29 February 2020

volume

20

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29 February 2020

issue

2

2 references

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29 February 2020

page(s)

2208-2228

1 reference

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Creative Commons Attribution

29 February 2020

copyright license

1 reference

17 September 2019

0 references

Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activation

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21 March 2017

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Clinical significance of the cytochrome P450 2C19 genetic polymorphism

21 March 2017

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Extraction studies of Tabernanthe iboga and Voacanga africana

21 March 2017

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Mechanisms of antiaddictive actions of ibogaine

21 March 2017

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18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats

21 March 2017

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Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development

21 March 2017

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Ascending-dose study of noribogaine in healthy volunteers: pharmacokinetics, pharmacodynamics, safety, and tolerability

21 March 2017

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Methadone, QTc prolongation and torsades de pointes: Current concepts, management and a hidden twist in the tale?

28 September 2017

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Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.

28 September 2017

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The G-protein-gated K channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation

28 September 2017

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Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile

28 September 2017

1 reference

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Distribution and function of sodium channel subtypes in human atrial myocardium

28 September 2017

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Ibogaine in the treatment of substance dependence

28 September 2017

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Life-threatening complications of ibogaine: three case reports

28 September 2017

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Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk

28 September 2017

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Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients

28 September 2017

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Fatalities temporally associated with the ingestion of ibogaine

28 September 2017

1 reference

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Ibogaine and the inhibition of acetylcholinesterase

28 September 2017

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Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration

28 September 2017

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Drug-Induced Long QT Syndrome

28 September 2017

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Increased Cardiac Risk in Concomitant Methadone and Diazepam Treatment: Pharmacodynamic Interactions in Cardiac Ion Channels

28 September 2017

1 reference

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Mechanisms of hypokalemia-induced ventricular arrhythmogenicity.

28 September 2017

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Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

28 September 2017

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Extracellular K concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines

28 September 2017

1 reference

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Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review

28 September 2017

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The promiscuous nature of the cardiac sodium current

28 September 2017

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hERG potassium channels and cardiac arrhythmia

28 September 2017

1 reference

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HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

28 September 2017

1 reference

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The impact of drug-induced QT interval prolongation on drug discovery and development

28 September 2017

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

28 September 2017

1 reference

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Mechanisms of action of ibogaine: relevance to putative therapeutic effects and development of a safer iboga alkaloid congener

28 September 2017

1 reference

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Ibogaine in the treatment of heroin withdrawal

28 September 2017

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28 September 2017

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Pharmacogenetics and drug-induced arrhythmias

28 September 2017

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In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats

28 September 2017

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Inhibition of human ether-a-go-go potassium channels by cocaine

28 September 2017

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Ibogaine: complex pharmacokinetics, concerns for safety, and preliminary efficacy measures

28 September 2017

1 reference

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Modulation of HERG potassium channels by extracellular magnesium and quinidine

28 September 2017

1 reference

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Medication development of ibogaine as a pharmacotherapy for drug dependence.

28 September 2017

1 reference

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Rapid inactivation determines the rectification and [K ]o dependence of the rapid component of the delayed rectifier K current in cardiac cells.

28 September 2017

1 reference

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Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline

28 September 2017

1 reference

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Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart

28 September 2017

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Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine

31 May 2018

1 reference

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Alteration of electroencephalogram and monoamine concentrations in rat brain following ibogaine treatment

31 May 2018

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Poisoning by sodium channel blocking agents

31 May 2018

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Ibogaine neurotoxicity: a re-evaluation

31 May 2018

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Peripheral cardiovascular effects of tabernanthine tartrate in anaesthetized rats

31 May 2018

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Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies

31 May 2018

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Mechanisms of Antiaddictive Actions of Ibogainea

31 May 2018

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18-Methoxycoronaridine (18-MC) and ibogaine: comparison of antiaddictive efficacy, toxicity, and mechanisms of action

21 January 2018

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Addiction research. Ibogaine therapy: a 'vast, uncontrolled experiment'.

21 January 2018

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A dose-response study of ibogaine-induced neuropathology in the rat cerebellum

21 January 2018

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Long-QT syndrome induced by the antiaddiction drug ibogaine.

21 January 2018

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21 January 2018

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Fatal case of a 27-year-old male after taking iboga in withdrawal treatment: GC-MS/MS determination of ibogaine and ibogamine in iboga roots and postmortem biological material

21 January 2018

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A case of death due to ibogaine use for heroin addiction: case report

21 January 2018

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Growing menace of ibogaine toxicity

21 January 2018

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The Total Synthesis of Iboga Alkaloids1

21 January 2018

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Total synthesis of ibogaine, epiibogaine and their analogues

21 January 2018

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Tissue distribution of ibogaine after intraperitoneal and subcutaneous administration.

21 January 2018

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Metabolism of 18-methoxycoronaridine, an ibogaine analog, to 18-hydroxycoronaridine by genetically variable CYP2C19.

21 January 2018

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Effects of quinine and quinidine on the transient outward and on the L-type Ca(2 ) current in rat ventricular cardiomyocytes

21 January 2018

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Prolonged QTc interval and risk of sudden cardiac death in a population of older adults

21 January 2018

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Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons

21 January 2018

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Development of novel medications for drug addiction. The legacy of an African shrub.

28 November 2018

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Liquid chromatography-electrospray mass spectrometry determination of ibogaine and noribogaine in human plasma and whole blood. Application to a poisoning involving Tabernanthe iboga root

28 November 2018

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12 December 2020

Noribogaine (12-hydroxyibogamine): a biologically active metabolite of the antiaddictive drug ibogaine

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12 December 2020

Effects of tabernanthine on calcium and catecholamine stimulated contractions of isolated vascular and cardiac muscle

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12 December 2020

Drug-induced prolongation of the QT interval: regulatory dilemmas and implications for approval and labelling of a new chemical entity

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12 December 2020

Ibogaine-associated ventricular tachyarrhythmias

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12 December 2020

Cardiac arrest after ibogaine ingestion

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12 December 2020

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

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Effects of acute alcohol infusion on duration and dispersion of QT interval in male patients with coronary artery disease and in healthy controls

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Effects of tabernanthine on various cardiovascular parameters in the rat and dog (author's transl)

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Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence

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Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity

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10.3390/MOLECULES20022208

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25642835 AND SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25642835 AND SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

25642835

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25642835 AND SRC:MED&resulttype=core&format=json