MAPK pathway activation in pilocytic astrocytoma (Q27006028)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

31 January 2021

MAPK pathway activation in pilocytic astrocytoma (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

3 April 2019

MAP kinase signaling system

2 references

18 January 2021

31 January 2021

pilocytic astrocytoma

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

Stefan M. Pfister

series ordinal

5

1 reference

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18 January 2020

3

Peter Lichter

2 references

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18 January 2020

author name string

Jan Gronych

series ordinal

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

Olaf Witt

series ordinal

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

1 reference

13 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

Cellular and Molecular Life Sciences

18 January 2020

1 June 2012

2 references

18 January 2021

31 January 2021

5 references

3 April 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

18 January 2021

31 January 2021

69

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

issue

11

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

1799-1811

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18 January 2020

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Nf1-dependent tumors require a microenvironment containing Nf1 /-- and c-kit-dependent bone marrow

21 March 2017

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 March 2017

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An integrated genomic analysis of human glioblastoma multiforme

21 March 2017

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21 March 2017

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 March 2017

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A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity

21 March 2017

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Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

21 March 2017

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Mutations of the BRAF gene in human cancer

21 March 2017

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Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

21 March 2017

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The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas

21 March 2017

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 March 2017

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Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

21 March 2017

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Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes

21 March 2017

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Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants

21 March 2017

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Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

21 March 2017

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

21 March 2017

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

7 April 2017

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Mosaic analysis with double markers reveals tumor cell of origin in glioma

7 April 2017

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BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.

28 September 2017

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Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

28 September 2017

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An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

28 September 2017

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Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

28 September 2017

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The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation

28 September 2017

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Survival and long-term health and cognitive outcomes after low-grade glioma

28 September 2017

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Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth

28 September 2017

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PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma

28 September 2017

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Activated MEK cooperates with Ink4a/Arf loss or Akt activation to induce gliomas in vivo

28 September 2017

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MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential

28 September 2017

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A multivariate analysis of factors determining tumor progression in childhood low-grade glioma: a population-based cohort study (CCLG CNS9702)

28 September 2017

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Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene

28 September 2017

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Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

28 September 2017

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Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas

28 September 2017

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Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.

28 September 2017

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MAPK pathway activation and the origins of pediatric low-grade astrocytomas.

28 September 2017

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Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.

28 September 2017

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Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours

28 September 2017

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GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma

28 September 2017

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28 September 2017

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A microhomology-mediated break-induced replication model for the origin of human copy number variation

28 September 2017

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28 September 2017

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Development of a novel mouse glioma model using lentiviral vectors

28 September 2017

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Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene

28 September 2017

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Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma

28 September 2017

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Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.

28 September 2017

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Constitutive activation of Raf-1 induces glioma formation in mice

28 September 2017

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The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

28 September 2017

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Pten haploinsufficiency accelerates formation of high-grade astrocytomas

28 September 2017

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High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

28 September 2017

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BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

28 September 2017

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28 September 2017

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BRAF(E600) in benign and malignant human tumours

28 September 2017

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Genomic analysis of pilocytic astrocytomas at 0.97 Mb resolution shows an increasing tendency toward chromosomal copy number change with age.

28 September 2017

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Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation

28 September 2017

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CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo.

28 September 2017

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Considerations on the role of chemotherapy and modern radiotherapy in the treatment of childhood low grade glioma.

28 September 2017

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Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

28 September 2017

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Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

28 September 2017

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Molecular pathogenesis of astrocytic tumours

28 September 2017

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Shared oligodendrocyte lineage gene expression in gliomas and oligodendrocyte progenitor cells

28 September 2017

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Transient neuronal but persistent astroglial activation of ERK/MAP kinase after focal brain injury in mice

28 September 2017

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Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

28 September 2017

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Characterisation of molecular alterations in microdissected archival gliomas.

28 September 2017

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The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory.

28 September 2017

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

28 September 2017

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The PEN5 epitope identifies an oligodendrocyte precursor cell population and pilocytic astrocytomas

28 September 2017

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Intracranial gliomas in neurofibromatosis type 1.

28 September 2017

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Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors

28 September 2017

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The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2.

28 September 2017

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Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas.

28 September 2017

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Ras oncogene mutations in childhood brain tumors.

28 September 2017

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A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

28 September 2017

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Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

28 September 2017

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RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology

31 May 2018

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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

31 May 2018

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Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

31 May 2018

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von Recklinghausen neurofibromatosis. II. Incidence of optic gliomata

31 May 2018

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Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

31 May 2018

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Impact of chemotherapy on disseminated low-grade glioma in children and adolescents: report from the HIT-LGG 1996 trial

31 May 2018

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Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization

21 January 2018

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Nonrandom chromosomal gains in pilocytic astrocytomas of childhood.

21 January 2018

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Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain

21 January 2018

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Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas

21 January 2018

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In vitro identification and functional characterization of glial precursor cells in human gliomas

21 January 2018

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Relevance of combinatorial profiles of intermediate filaments and transcription factors for glioma histogenesis

21 January 2018

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RAS/RAF pathway activation in gliomas: the result of copy number gains rather than activating mutations

21 January 2018

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Natural history and management of low-grade glioma in NF-1 children

21 January 2018

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A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype-phenotype correlations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Tumor development in three patients with Noonan syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

A 16-year-old male with Noonan's syndrome develops progressive scoliosis and deteriorating gait

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Pilocytic astrocytoma in a child with Noonan syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

PTEN mutations in gliomas and glioneuronal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

A negative feedback signaling network underlies oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/S00018-011-0898-9

BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

Low-grade astrocytoma: a decade of experience at St. Jude Children's Research Hospital

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350769

Chromosomal translocations as a mechanism of BRAF activation in two cases of large congenital melanocytic nevi

28 November 2018

1 reference

12 December 2020

Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival

1 reference

12 December 2020

The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway

1 reference

12 December 2020

Genetics of neurofibromatosis 1 in Japan: mutation rate and paternal age effect

1 reference

12 December 2020

10.1007/S00018-011-0898-9

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

18 January 2020

1037922098

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22159586 AND SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

22159586

2 references