Recent advances toward a molecular mechanism of efflux pump inhibition (Q27004685)

Son T. Nguyen

series ordinal

2

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language of work or name

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2015

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Frontiers in Microbiology

published in

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volume

6

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page(s)

421

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Structure of the AcrAB–TolC multidrug efflux pump

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Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution

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Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa

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β-Lactam selectivity of multidrug transporters AcrB and AcrD resides in the proximal binding pocket

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The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria

28 September 2017

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Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.

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Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

28 September 2017

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Molecular dynamics simulations and drug discovery

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28 September 2017

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Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations

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Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli

28 September 2017

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Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli

28 September 2017

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Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update.

28 September 2017

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28 September 2017

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Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling

28 September 2017

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Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

28 September 2017

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Drug transport mechanism of the AcrB efflux pump

28 September 2017

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Inhibitors of multidrug resistant efflux systems in bacteria

28 September 2017

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Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism

28 September 2017

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Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.

28 September 2017

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Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux

28 September 2017

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Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins

28 September 2017

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Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway

28 September 2017

1 reference

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Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria

28 September 2017

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Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Molecular dynamics simulations of biomolecules

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Computational study of correlated domain motions in the AcrB efflux transporter.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Recognition of imipenem and meropenem by the RND-transporter MexB studied by computer simulations

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Substrate path in the AcrB multidrug efflux pump of Escherichia coli.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

A promiscuous conformational switch in the secondary multidrug transporter MdfA.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Inactivation of efflux pumps abolishes bacterial biofilm formation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space

31 May 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Porter domain opening and closing motions in the multi-drug efflux transporter AcrB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Functionality mapping on internal surfaces of multidrug transporter AcrB based on molecular theory of solvation: implications for drug efflux pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-beta-naphthylamide

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Peptidomimetics of efflux pump inhibitors potentiate the activity of levofloxacin in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Role of water during the extrusion of substrates by the efflux transporter AcrB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Drug uptake pathways of multidrug transporter AcrB studied by molecular simulations and site-directed mutagenesis experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Covalently linked AcrB giant offers a new powerful tool for mechanistic analysis of multidrug efflux in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Three ways in, one way out: Water dynamics in the trans‐membrane domains of the inner membrane translocase AcrB

21 January 2018

1 reference

https://api.crossref.org/works/10.3389/FMICB.2015.00421

Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4419859

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: exploration of aromatic substituents

28 November 2018

1 reference

12 December 2020

Effect of sulbactam on anti-pseudomonal activity of beta-lactam antibiotics in cells producing various levels of the MexAB-OprM efflux pump and beta-lactamase

1 reference

12 December 2020

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate

1 reference

12 December 2020

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

1 reference

12 December 2020

Identifiers

DOI

10.3389/FMICB.2015.00421

1 reference

release_6575irra6jeqfotfbwtxhuu2y4

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

25999939

1 reference