Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation (Q27001595)

Thompson PR

series ordinal

2

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Hofseth LJ

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3

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language of work or name

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2015

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16

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issue

7

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page(s)

700-10

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Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis

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Citrullination: a small change for a protein with great consequences for rheumatoid arthritis

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Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors

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Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse

21 March 2017

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PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

21 March 2017

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Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

21 March 2017

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Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

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Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis

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Human PAD4 regulates histone arginine methylation levels via demethylimination

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Structural basis for Ca(2 )-induced activation of human PAD4

21 March 2017

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Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6

21 March 2017

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The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest

21 March 2017

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Citrullination regulates pluripotency and histone H1 binding to chromatin

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Potential role for PAD2 in gene regulation in breast cancer cells.

21 March 2017

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Functional analysis of the profilaggrin N-terminal peptide: identification of domains that regulate nuclear and cytoplasmic distribution

21 March 2017

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microRNAs as oncogenes and tumor suppressors

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7 April 2017

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Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells.

28 September 2017

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Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus

28 September 2017

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Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates

28 September 2017

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Pluripotency: citrullination unravels stem cells

28 September 2017

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Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway

28 September 2017

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Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

28 September 2017

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Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis

28 September 2017

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RefSeq: an update on mammalian reference sequences

28 September 2017

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Neutrophil extracellular traps (NETs) - formation and implications

28 September 2017

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Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.

28 September 2017

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NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis

28 September 2017

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D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy

28 September 2017

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The protein arginine deiminases: Structure, function, inhibition, and disease.

28 September 2017

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Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis

28 September 2017

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Identification of PADI2 as a potential breast cancer biomarker and therapeutic target

28 September 2017

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Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines.

28 September 2017

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Potential role for PADI-mediated histone citrullination in preimplantation development

28 September 2017

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The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.

28 September 2017

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Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

28 September 2017

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Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus.

28 September 2017

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Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.

28 September 2017

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Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity

28 September 2017

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Citrullination of Inhibitor of Growth 4 (ING4) by Peptidylarginine Deminase 4 (PAD4) Disrupts the Interaction between ING4 and p53

28 September 2017

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Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

28 September 2017

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N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.

28 September 2017

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Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices

28 September 2017

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Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages

28 September 2017

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Protein arginine deiminase 4: a target for an epigenetic cancer therapy

28 September 2017

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Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis.

28 September 2017

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Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

28 September 2017

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28 September 2017

PADI4 and tumourigenesis

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Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression

28 September 2017

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Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential

28 September 2017

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Recognition of the N-terminal histone H2A and H3 peptides by peptidylarginine deiminase IV.

28 September 2017

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Nucleophosmin blocks mitochondrial localization of p53 and apoptosis

28 September 2017

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Increased PADI4 expression in blood and tissues of patients with malignant tumors

28 September 2017

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Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

28 September 2017

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Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis

28 September 2017

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Regulation of p53 target gene expression by peptidylarginine deiminase 4

28 September 2017

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Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases.

28 September 2017

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Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock?

28 September 2017

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Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.

28 September 2017

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Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.

28 September 2017

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Citrullination: a posttranslational modification in health and disease

28 September 2017

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PAD: the smoking gun behind arginine methylation signaling?

28 September 2017

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Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.

28 September 2017

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Deimination of 70-kD nuclear protein during epidermal apoptotic events in vitro

28 September 2017

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Selective Deimination of Vimentin in Calcium Ionophore-Induced Apoptosis of Mouse Peritoneal Macrophages

28 September 2017

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Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin

28 September 2017

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Preferential deimination of keratin K1 and filaggrin during the terminal differentiation of human epidermis

28 September 2017

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Properties of peptidylarginine deiminase from the epidermis of newborn rats

28 September 2017

1 reference

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Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase.

28 September 2017

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The role of the vimentin intermediate filaments in rat 3Y1 cells elucidated by immunoelectron microscopy and computer-graphic reconstruction

28 September 2017

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Citrullination is an inflammation-dependent process

28 September 2017

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A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation

31 May 2018

1 reference

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Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages

31 May 2018

1 reference

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The origin of citrulline-containing proteins in the hair follicle and the chemical nature of trichohyalin, an intracellular precursor

31 May 2018

1 reference

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Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease.

31 May 2018

1 reference

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RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells

28 November 2018

1 reference

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Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors

28 November 2018

1 reference

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Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro

28 November 2018

1 reference

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Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.

28 November 2018

1 reference

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The inhibition of antithrombin by peptidylarginine deiminase 4 may contribute to pathogenesis of rheumatoid arthritis

28 November 2018

1 reference

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Calcium orchestrates apoptosis.

28 November 2018

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Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase V.

28 November 2018

1 reference

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Immunohistochemical localization of citrullinated proteins in adult rat brain

28 November 2018

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Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520219

The developmental expression and activity of peptidylarginine deiminase in the mouse

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520219

Rapid release and unusual stability of immunodominant peptide 45-89 from citrullinated myelin basic protein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520219

A novel microtubule independent effect of paclitaxel: the inhibition of peptidylarginine deiminase from bovine brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520219

Deimination of Human Myelin Basic Protein by a Peptidylarginine Deiminase from Bovine Brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4520219

Combined biochemical and immunochemical comparison of peptidylarginine deiminases present in various tissues

28 November 2018

1 reference

12 December 2020

Regulation of histone modification and chromatin structure by the p53–PADI4 pathway

1 reference

12 December 2020

Decreased deiminated keratin K1 in psoriatic hyperproliferative epidermis

1 reference

12 December 2020

Detection of deiminated proteins in rat skin: probing with a monospecific antibody after modification of citrulline residues

1 reference

12 December 2020

Ca2 -dependent deimination-induced disassembly of intermediate filaments involves specific modification of the amino-terminal head domain

1 reference

12 December 2020

Specificity and mode of action of the muscle-type protein-arginine deiminase

1 reference

12 December 2020

Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein

1 reference

12 December 2020

Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice

1 reference

12 December 2020

1 reference

12 December 2020

Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population

1 reference

12 December 2020

Content of Citrulline and Other Amino-Acids in a Protein of Hair Follicles

1 reference

12 December 2020

10.2174/1389450116666150202160954

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

25642720

1 reference