Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench (Q26995645)

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7 February 2020

title

Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench (English)

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7 February 2020

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3

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7 February 2020

author name string

Stefan Fritz

4

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7 February 2020

Dirk Bausch

5

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7 February 2020

Janivette Alsina

7

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7 February 2020

Birte Kulemann

8

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7 February 2020

Joo Kyung Park

9

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7 February 2020

Junpei Yamaguchi

10

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7 February 2020

Jennifer LaFemina

11

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7 February 2020

David E Rosow

1

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7 February 2020

Andrew S Liss

2

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7 February 2020

Nakul P Valsangkar

6

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7 February 2020

Sarah P Thayer

12

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7 February 2020

language of work or name

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6 July 2012

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7 February 2020

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7 February 2020

volume

152

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7 February 2020

issue

3 Suppl 1

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7 February 2020

page(s)

S19-32

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

7 February 2020

cites work

1 reference

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

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Stem cells, cancer, and cancer stem cells

21 March 2017

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21 March 2017

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21 March 2017

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Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 March 2017

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Identification of pancreatic cancer stem cells

21 March 2017

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Mutations affecting segment number and polarity in Drosophila

21 March 2017

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Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function

21 March 2017

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Regulation of pancreas development by hedgehog signaling

21 March 2017

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Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

21 March 2017

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 March 2017

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

7 April 2017

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

7 April 2017

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

7 April 2017

1 reference

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Novel agents for the treatment of pancreatic adenocarcinoma. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011

7 April 2017

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Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

28 September 2017

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Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

28 September 2017

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Beta-cell growth and regeneration: replication is only part of the story

28 September 2017

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Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations

28 September 2017

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Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells

28 September 2017

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Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways

28 September 2017

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Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia

28 September 2017

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Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

28 September 2017

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Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

28 September 2017

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Hedgehog signalling: emerging evidence for non-canonical pathways

28 September 2017

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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

28 September 2017

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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

28 September 2017

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Sonic hedgehog promotes desmoplasia in pancreatic cancer

28 September 2017

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An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

28 September 2017

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A paracrine requirement for hedgehog signalling in cancer

28 September 2017

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Pancreatic cancer stem cells.

28 September 2017

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Hedgehog signalling in endocrine development and disease.

28 September 2017

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Primers on molecular pathways GLI: more than just Hedgehog?

28 September 2017

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Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

28 September 2017

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In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia

28 September 2017

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Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.

28 September 2017

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Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo

28 September 2017

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Pancreas and beta-cell development: from the actual to the possible

28 September 2017

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Hedgehog/Ras interactions regulate early stages of pancreatic cancer

28 September 2017

1 reference

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Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer

28 September 2017

1 reference

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Sonic hedgehog is an early developmental marker of intraductal papillary mucinous neoplasms: clinical implications of mRNA levels in pancreatic juice.

28 September 2017

1 reference

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Hedgehog signaling in the normal and diseased pancreas

28 September 2017

1 reference

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Hedgehog signaling in pancreas development and disease

28 September 2017

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Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells.

28 September 2017

1 reference

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Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?

28 September 2017

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Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis

28 September 2017

1 reference

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Hedgehog signaling in pancreas development

28 September 2017

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Notochord repression of endodermal Sonic hedgehog permits pancreas development

28 September 2017

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DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

28 September 2017

1 reference

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Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells.

31 May 2018

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Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells

31 May 2018

1 reference

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

31 May 2018

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Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

31 May 2018

1 reference

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Hedgehog signaling is required for effective regeneration of exocrine pancreas

31 May 2018

1 reference

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Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers

31 May 2018

1 reference

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Ductal cancers of the pancreas frequently express markers of gastrointestinal epithelial cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3806061

Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling

31 May 2018

1 reference

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Inhibition of ocular neovascularization by hedgehog blockade.

28 November 2018

1 reference

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Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3806061

Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas

28 November 2018

1 reference

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Notochord to endoderm signaling is required for pancreas development

28 November 2018

1 reference

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Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression

28 November 2018

1 reference

12 December 2020

Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling

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12 December 2020

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract

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12 December 2020

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

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12 December 2020

A CONGENITAL CYCLOPIAN-TYPE MALFORMATION IN LAMBS INDUCED BY MATERNAL INGESTION OF A RANGE PLANT, VERATRUM CALIFORNICUM

1 reference

12 December 2020

10.1016/J.SURG.2012.05.030

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22770959 AND SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22770959 AND SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

22770959

2 references