Tuberculosis drug discovery in the post-post-genomic era (Q26864729)

Jan Rybniker

series ordinal

2

1 reference

language of work or name

1 reference

February 2014

1 reference

1 February 2014

5 references

23 March 2019

20 June 2019

22 June 2019

19 September 2019

25 November 2020

EMBO Molecular Medicine

6 references

23 March 2019

20 June 2019

22 June 2019

19 September 2019

25 November 2020

6

1 reference

issue

2

1 reference

page(s)

158-68

1 reference

Creative Commons Attribution 3.0 Unported

copyright license

5 references

23 March 2019

20 June 2019

22 June 2019

19 September 2019

on focus list of Wikimedia project

25 November 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs

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The mechanism of action of PA-824: Novel insights from transcriptional profiling

21 March 2017

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PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

21 March 2017

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OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice

21 March 2017

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Evolution of glyoxylate cycle enzymes in Metazoa: evidence of multiple horizontal transfer events and pseudogene formation

21 March 2017

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Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor

21 March 2017

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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

21 March 2017

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Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

21 March 2017

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Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. tuberculosis Malate Synthase

21 March 2017

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Towards a new tuberculosis drug: pyridomycin - nature's isoniazid

21 March 2017

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Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

21 March 2017

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Synthetic EthR inhibitors boost antituberculous activity of ethionamide

21 March 2017

1 reference

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A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

21 March 2017

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Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases

21 March 2017

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Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3

21 March 2017

1 reference

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Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB

21 March 2017

1 reference

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Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

21 March 2017

1 reference

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Leads for antitubercular compounds from kinase inhibitor library screens

21 March 2017

1 reference

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Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen

21 March 2017

1 reference

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High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors

21 March 2017

1 reference

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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

21 March 2017

1 reference

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Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

21 March 2017

1 reference

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Genes required for mycobacterial growth defined by high density mutagenesis

21 March 2017

1 reference

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Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Activation of the pro-drug ethionamide is regulated in mycobacteria

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

A new drug for an old bug

21 March 2017

1 reference

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

21 March 2017

1 reference

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

7 April 2017

1 reference

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

7 April 2017

1 reference

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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

7 April 2017

1 reference

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Advances in the development of new tuberculosis drugs and treatment regimens

28 September 2017

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Host gene-encoded severe lung TB: from genes to the potential pathways

28 September 2017

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Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages

28 September 2017

1 reference

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Back to the future: a new 'old' lead for tuberculosis.

28 September 2017

1 reference

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Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Adjunct immunotherapies for tuberculosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Recent advances in antitubercular natural products.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Express path analysis identifies a tyrosine kinase Src-centric network regulating divergent host responses to Mycobacterium tuberculosis infection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Tuberculosis drugs: new candidates and how to find more

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

High-content screening in infectious diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Depletion of antibiotic targets has widely varying effects on growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Simple model for testing drugs against nonreplicating Mycobacterium tuberculosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Global tuberculosis drug development pipeline: the need and the reality.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Aligning antimicrobial drug discovery with complex and redundant host-pathogen interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Selective killing of nonreplicating mycobacteria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

Mechanisms of drug resistance in Mycobacterium tuberculosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3927952

The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action

31 May 2018

1 reference

https://api.crossref.org/works/10.1002/EMMM.201201772

TubercuList--10 years after

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/EMMM.201201772

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/EMMM.201201772

Detection and treatment of subclinical tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002/EMMM.201201772

The absorption and toxicity of ethionamide

21 January 2018

1 reference

12 December 2020

Local pulmonary immunotherapy with siRNA targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice

1 reference

12 December 2020

A new antibiotic, pyridomycin

1 reference

12 December 2020

Animal models of tuberculosis

1 reference

12 December 2020

EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets

1 reference

https://api.crossref.org/works/10.1002/EMMM.201201772

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/EMMM.201201772

1 reference

1 reference

1 reference

PubMed publication ID

24401837

1 reference