The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily (Q26830810)

language of work or name

1 reference

23 November 2012

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Journal of Biological Chemistry

published in

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volume

287

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issue

48

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page(s)

40207-15

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Structure and pharmacology of pentameric receptor channels: from bacteria to brain

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Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

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Structure and gating mechanism of the acetylcholine receptor pore

7 April 2017

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

7 April 2017

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ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

7 April 2017

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

7 April 2017

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Use of a snake venom toxin to characterize the cholinergic receptor protein

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Allostery and the Monod-Wyman-Changeux model after 50 years

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Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

28 September 2017

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Intracellular complexes of the beta2 subunit of the nicotinic acetylcholine receptor in brain identified by proteomics

28 September 2017

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A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

28 September 2017

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Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

28 September 2017

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28 September 2017

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Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2 -binding sites

28 September 2017

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Emerging structure of the nicotinic acetylcholine receptors

28 September 2017

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Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

28 September 2017

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Molecular cloning of cDNA coding for the gamma subunit of Torpedo acetylcholine receptor

28 September 2017

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Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata

28 September 2017

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Identification of a cDNA clone coding for the acetylcholine binding subunit of Torpedo marmorata acetylcholine receptor

28 September 2017

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Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences

28 September 2017

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Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor gamma subunit

28 September 2017

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Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain

28 September 2017

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Spontaneous openings of the acetylcholine receptor channel

28 September 2017

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Time-resolved photolabeling by the noncompetitive blocker chlorpromazine of the acetylcholine receptor in its transiently open and closed ion channel conformations

28 September 2017

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Expression of functional acetylcholine receptor from cloned cDNAs

28 September 2017

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Structural homology of Torpedo californica acetylcholine receptor subunits

28 September 2017

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The molecular cloning and characterisation of cDNA coding for the α subunit of the acetyl-choline receptor

28 September 2017

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Primary structure of α-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence

28 September 2017

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Reduction and specific alkylation of the receptor for acetylcholine

28 September 2017

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Affinity labeling of the acetylcholine-receptor

28 September 2017

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Reconstitution of a chemically excitable membrane

28 September 2017

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Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine

28 September 2017

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Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata

28 September 2017

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Interaction of a spin-labeled long chain acylcholine with the cholinergic receptor protein in its membrane environment

28 September 2017

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A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties

28 September 2017

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X-ray diffraction study of membrane fragments rich in acetylcholine receptor protein prepared from the electric organ of Torpedo marmorata

31 May 2018

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Purification and Properties of the Cholinergic Receptor Protein from Electrophorus electricus Electric Tissue

31 May 2018

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Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. 3. Effects of local anaesthetics on the binding of the tritiated alpha-neurotoxin

31 May 2018

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Molecular weight and quaternary structure of the cholinergic receptor protein extracted by detergents from Electrophorus electricus electric tissue

31 May 2018

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Interaction of a fluorescent ligand with membrane-bound cholinergic receptor from Torpedo marmorata

31 May 2018

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The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus.

31 May 2018

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Affinity-labeling of purified acetylcholine receptor from Torpedo californica.

31 May 2018

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Ultrastructure of isolated membranes of Torpedo electric tissue

31 May 2018

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Characterization of the transient agonist-triggered state of the acetylcholine receptor rapidly labeled by the noncompetitive blocker [3H]chlorpromazine: additional evidence for the open channel conformation

31 May 2018

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Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit

31 May 2018

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Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

31 May 2018

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Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor

31 May 2018

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Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel

31 May 2018

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Potentiation of nicotinic receptor response by external calcium in rat central neurons

31 May 2018

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Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

31 May 2018

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Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors

31 May 2018

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Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. V. Qualitative correlation between pharmacological effects and equilibration processes of the cholinergic receptor protein as revealed by the structural probe

31 May 2018

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Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ. IV. Quinacrine: a fluorescent probe for the conformational transitions of the cholinergic receptor protein in its membrane-bound state.

31 May 2018

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Kinetics of agonist-mediated transitions in state of the cholinergic receptor.

31 May 2018

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Amino terminal amino acid sequence of the major polypeptide subunit of Torpedocalifornica acetylcholine receptor

31 May 2018

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Immunochemical similarities between subunits of acetylcholine receptors from Torpedo, Electrophorus, and mammalian muscle

31 May 2018

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The amino-terminal sequence of the 40 000 molecular weight subunit of the acetylcholine receptor protein fromTorpedo marmorata

31 May 2018

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Fast Kinetic Studies on the Allosteric Interactions between Acetylcholine Receptor and Local Anesthetic Binding Sites

31 May 2018

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Fast Kinetic Studies on the Interaction of a Fluorescent Agonist with the Membrane-Bound Acetylcholine Receptor from Torpedo marmorata

31 May 2018

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Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

31 May 2018

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Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities

21 January 2018

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Rapid kinetics of agonist binding and permeability response analyzed in parallel on acetylcholine receptor rich membranes from Torpedo marmorata.

21 January 2018

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Conversion of particulate tyrosinase to soluble form and to desialylated tyrosinase in human malignant melanoma

21 January 2018

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Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata

21 January 2018

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Biological Sciences: Isolation of the Cholinergic Receptor Protein of Torpedo Electric Tissue

28 November 2018

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In vitro phosphorylation of the acetylcholine receptor

21 January 2018

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Conditions for the selective labelling of the 66 000 dalton chain of the acetylcholine receptor by the covalent non-competitive blocker 5-azido-[3H]trimethisoquin

21 January 2018

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12 December 2020

Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes

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12 December 2020

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site

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12 December 2020

Fast kinetic studies on the interaction of cholinergic agonists with the membrane-bound acetylcholine receptor from Torpedo marmorata as revealed by quinacrine fluorescence

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12 December 2020

Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata

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12 December 2020

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites

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12 December 2020

In Vitro excitation of purified membrane fragments by cholinergic agonists : I. Pharmalogical properties of the excitable membrane fragments

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12 December 2020

Acetylcholine receptor: complex of homologous subunits

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12 December 2020

Affinity labeling of antibodies to the p-azophenyltrimethylammonium hapten and a structural relationship among antibody active sites of different specificities

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12 December 2020

Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata in the millisecond time range: resolution of an "intermediate" conformational transition and evidence for positive cooperative effects

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12 December 2020

Separation of the receptor protein of acetylcholine and acetylcholinesterase

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12 December 2020

The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits

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12 December 2020

Crosslinking of alpha-bungarotoxin to the acetylcholine receptor from Torpedo marmorata by ultraviolet light irradiation

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12 December 2020

The biochemistry of an acetylcholine receptor

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12 December 2020

Progress in the purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography

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12 December 2020

Location of a threonine residue in the α -subunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel

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12 December 2020

[The high affinity binding site for chlorpromazine is present only as a single copy per cholinergic receptor molecule and is shared by four polypeptide chains]

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12 December 2020

[Separation of excitable membranes from the electric organ of Electrophorus electricus]

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12 December 2020

Isolation of the nicotinic acetylcholine receptor by biospecific chromatography on insolubilized Naja naja neurotoxin

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12 December 2020

ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION

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12 December 2020

Reconstitution of carbamylcholine-dependent sodium ion flux and desensitization of the acetylcholine receptor from Torpedo californica

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12 December 2020

Use of affinity chromatography for acetylcholine receptor purification

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12 December 2020

Extraction from electric tissue of gymnotus of a protein presenting several typical properties characteristic of the physiological receptor of acetylcholine

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12 December 2020

Demonstration of the excitation by cholinergic agonists from fractions of purified membranes, in vitro

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12 December 2020

Purification fromTorpedo marmorataelectric tissue of membrane fragments particularly rich in cholinergic receptor protein

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12 December 2020

Large-scale purification of the acetylcholine-receptor protein in its membrane-bound and detergent-extracted forms from Torpedo marmorata electric organ

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12 December 2020

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the beta and delta chains

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12 December 2020

Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor

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12 December 2020

Effects of inhibitors of the binding of iodinated alpha-bungarotoxin to acetylcholine receptors in rat muscle

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12 December 2020