The Role of Calcium and Cyclic AMP in PKD (Q26824644)

language of work or name

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November 2015

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Polycystic Kidney Disease

PubMed

published in

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page(s)

171-196

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Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway

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Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

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7 January 2021

Cyclosporine A suppresses cyclooxygenase-2 expression in the rat kidney.

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Cyclosporin A administration during pregnancy induces a permanent nephron deficit in young rabbits

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7 January 2021

Differential expression of calcineurin A isoforms in the diabetic kidney

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7 January 2021

Chloride secretion by renal collecting ducts

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7 January 2021

Transcriptional regulation by calcium, calcineurin, and NFAT

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Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

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Rosiglitazone inhibits cell proliferation by inducing G1 cell cycle arrest and apoptosis in ADPKD cyst-lining epithelia cells

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Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent

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Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation

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Tolvaptan inhibits ERK-dependent cell proliferation, Cl−secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin

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7 January 2021

Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels

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Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells

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7 January 2021

In vitro fluid secretion by epithelium from polycystic kidneys

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7 January 2021

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

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NFAT control of innate immunity

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cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4.

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Loss of calcineurin Aalpha results in altered trafficking of AQP2 and in nephrogenic diabetes insipidus

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

Calcium ameliorates renal cyst growth in metanephric organ culture: a morphological study

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Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

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7 January 2021

Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells

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7 January 2021

Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease

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7 January 2021

Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na( ),K( ),2Cl(-) Co-transporter-dependent cystic dilation

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

Identification of a forskolin-like molecule in human renal cysts

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

Vasopressin directly regulates cyst growth in polycystic kidney disease

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

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Triptolide reduces cystogenesis in a model of ADPKD.

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease

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7 January 2021

Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

Lanreotide and its Potential Applications in Polycystic Kidney and Liver Diseases

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7 January 2021

CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD.

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https://api.crossref.org/works/10.15586/CODON.PKD.2015.CH8

7 January 2021

10.15586/CODON.PKD.2015.CH8

Identifiers

DOI

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PubMed publication ID

27512791

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