TGF-β Signaling via TAK1 Pathway: Role in Kidney Fibrosis (Q26824337)

TGF-β Signaling via TAK1 Pathway: Role in Kidney Fibrosis (English)

1 reference

https://api.crossref.org/works/10.1016/J.SEMNEPHROL.2012.04.003

7 January 2025

author name string

Mary E. Choi

series ordinal

1

1 reference

Yan Ding

series ordinal

2

1 reference

Sung Il Kim

series ordinal

3

1 reference

language of work or name

1 reference

May 2012

1 reference

full work available at URL

https://europepmc.org/articles/pmc3407377?pdf=render

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22835455

https://europepmc.org/articles/PMC3407377

7 January 2025

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22835455

https://europepmc.org/articles/PMC3407377?pdf=render

7 January 2025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22835455

https://doi.org/10.1016/j.semnephrol.2012.04.003

7 January 2025

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22835455

https://api.elsevier.com/content/article/PII:S0270929512000630?httpAccept=text/xml

7 January 2025

1 reference

https://api.crossref.org/works/10.1016/J.SEMNEPHROL.2012.04.003

https://api.elsevier.com/content/article/PII:S0270929512000630?httpAccept=text/plain

7 January 2025

1 reference

https://api.crossref.org/works/10.1016/J.SEMNEPHROL.2012.04.003

7 January 2025

published in

Seminars in Nephrology

1 reference

volume

32

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issue

3

1 reference

page(s)

244-52

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Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells

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Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

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Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway

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TAB3, a new binding partner of the protein kinase TAK1

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Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

7 April 2017

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7 April 2017

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7 April 2017

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

7 April 2017

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7 April 2017

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TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

7 April 2017

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TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

7 April 2017

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

7 April 2017

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7 April 2017

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TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop

7 April 2017

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

7 April 2017

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

7 April 2017

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HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81

7 April 2017

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Regulation of the TAK1 signaling pathway by protein phosphatase 2C

7 April 2017

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7 April 2017

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7 April 2017

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ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

7 April 2017

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

7 April 2017

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Wnt activates the Tak1/Nemo-like kinase pathway

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.

7 April 2017

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A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

28 September 2017

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TGF-β1 Protects against Mesangial Cell Apoptosis via Induction of Autophagy

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

28 September 2017

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28 September 2017

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Non-Smad TGF-beta signals

28 September 2017

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Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors

28 September 2017

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Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7.

28 September 2017

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Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase.

28 September 2017

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Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways

28 September 2017

1 reference

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28 September 2017

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Transforming growth factor-beta signal transduction and progressive renal disease

28 September 2017

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Obstructive nephropathy and renal fibrosis

28 September 2017

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28 September 2017

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Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

28 September 2017

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28 September 2017

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28 September 2017

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TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

28 September 2017

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28 September 2017

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Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney

28 September 2017

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Production of transforming growth factor beta 1 during repair of arterial injury

28 September 2017

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Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells

28 September 2017

1 reference

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Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

31 May 2018

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Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

31 May 2018

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Transforming growth factor beta activation of p44mapk in proliferating cultures of epithelial cells

31 May 2018

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TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney.

31 May 2018

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JNK signalling in human and experimental renal ischaemia/reperfusion injury.

28 November 2018

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Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.

28 November 2018

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Protective effects of FR167653 on chronic allograft nephropathy by inhibiting p38 MAPK in rats.

28 November 2018

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Pirfenidone Slows Renal Function Decline in Patients with Focal Segmental Glomerulosclerosis

28 November 2018

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A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.

28 November 2018

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Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377

Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377

Requirement of TGF-beta receptor-dependent activation of c-Jun N-terminal kinases (JNKs)/stress-activated protein kinases (Sapks) for TGF-beta up-regulation of the urokinase-type plasminogen activator receptor

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3407377

Transforming growth factor-beta1 induces collagen synthesis and accumulation via p38 mitogen-activated protein kinase (MAPK) pathway in cultured L(6)E(9) myoblasts

28 November 2018

1 reference

12 December 2020

It's a Smad world: regulation of TGF-beta signaling in the kidney

1 reference

12 December 2020

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

1 reference

12 December 2020

Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

1 reference

12 December 2020

Recombinant human anti–transforming growth factor β1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192

1 reference

12 December 2020

TGF-beta-activated kinase 1 and TAK1-binding protein 1 cooperate to mediate TGF-beta1-induced MKK3-p38 MAPK activation and stimulation of type I collagen

1 reference

12 December 2020

Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes

1 reference

12 December 2020

A pathogenic role for JNK signaling in experimental anti-GBM glomerulonephritis

1 reference

12 December 2020

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney

1 reference

12 December 2020

A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta

1 reference

12 December 2020

p38 Mitogen-activated protein kinase activation and cell localization in human glomerulonephritis: correlation with renal injury

1 reference

12 December 2020

The role of p38alpha mitogen-activated protein kinase activation in renal fibrosis

1 reference

12 December 2020

Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

1 reference

12 December 2020

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.

1 reference

12 December 2020

Identifiers

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22835455

7 January 2025

1 reference

1 reference