Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation (Q26823896)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

title

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

2

1 reference

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18 January 2020

author name string

Hao Wu

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

1 reference

1 December 2011

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

volume

25

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

issue

23

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

2436-2452

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites

18 January 2020

cites work

1 reference

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

7 April 2017

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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair

7 April 2017

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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

7 April 2017

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

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7 April 2017

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7 April 2017

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Human DNA methylomes at base resolution show widespread epigenomic differences

7 April 2017

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7 April 2017

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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

7 April 2017

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

7 April 2017

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7 April 2017

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Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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UHRF1 plays a role in maintaining DNA methylation in mammalian cells

7 April 2017

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7 April 2017

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DNA methylation patterns and epigenetic memory

7 April 2017

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The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

7 April 2017

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7 April 2017

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Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

7 April 2017

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Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells

7 April 2017

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TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

7 April 2017

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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

7 April 2017

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Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells

7 April 2017

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

7 April 2017

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

7 April 2017

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PGC7/Stella protects against DNA demethylation in early embryogenesis

7 April 2017

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7 April 2017

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7 April 2017

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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

7 April 2017

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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

7 April 2017

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7 April 2017

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Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

28 September 2017

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28 September 2017

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Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

28 September 2017

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28 September 2017

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28 September 2017

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5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

28 September 2017

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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

28 September 2017

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Active DNA demethylation: many roads lead to Rome.

28 September 2017

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Direct detection of DNA methylation during single-molecule, real-time sequencing

28 September 2017

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CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

28 September 2017

1 reference

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Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

28 September 2017

1 reference

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IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

28 September 2017

1 reference

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Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons.

28 September 2017

1 reference

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Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

28 September 2017

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A role for the elongator complex in zygotic paternal genome demethylation

28 September 2017

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Active DNA demethylation mediated by DNA glycosylases

28 September 2017

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Acquired mutations in TET2 are common in myelodysplastic syndromes

28 September 2017

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Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

The colorful history of active DNA demethylation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Epigenetic events in mammalian germ-cell development: reprogramming and beyond

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Cancer epigenetics: modifications, screening, and therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Genes of the thymidine salvage pathway: thymine-7-hydroxylase from a Rhodotorula glutinis cDNA library and iso-orotate decarboxylase from Neurospora crassa

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

A new pyrimidine base from bacteriophage nucleic acids

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Active demethylation of the paternal genome in the mouse zygote

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Chromosome methylation patterns during mammalian preimplantation development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Quantification of the sixth DNA base hydroxymethylcytosine in the brain

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Cloning and characterization of Rhodotorula glutinis thymine hydroxylase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Reversing DNA methylation: new insights from neuronal activity-induced Gadd45b in adult neurogenesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243055

Mitochondria and the death of oocytes

28 November 2018

1 reference

12 December 2020

Epigenetic reprogramming in mouse primordial germ cells

1 reference

12 December 2020

Common 4q24 deletion in four cases of hematopoietic malignancy: early stem cell involvement?

1 reference

12 December 2020

DNMT3A mutations in acute myeloid leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.179184.111

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22156206 AND SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

22156206

2 references