RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression (Q26800112)

AKT serine/threonine kinase 1

22 December 2019

1 reference

1 September 2020

1 reference

Karine A Cohen-Solal

1

0 references

Rajeev K Boregowda

series ordinal

2

0 references

Ahmed Lasfar

series ordinal

3

0 references

language of work or name

English

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publication date

25 July 2015

7 references

3 April 2019

30 June 2019

2 August 2019

28 September 2019

18 December 2019

22 December 2019

1 September 2020

7 references

3 April 2019

30 June 2019

2 August 2019

28 September 2019

18 December 2019

22 December 2019

1 September 2020

14

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issue

1

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page(s)

137

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copyright license

Creative Commons Attribution

7 references

3 April 2019

30 June 2019

2 August 2019

28 September 2019

18 December 2019

22 December 2019

1 September 2020

0 references

on focus list of Wikimedia project

ScienceSource

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cites work

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RUNX2 is overexpressed in melanoma cells and mediates their migration and invasion

28 September 2017

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Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation

28 September 2017

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Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells

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RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response

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Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway

28 September 2017

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Oxidative stress induces proliferation of colorectal cancer cells by inhibiting RUNX3 and activating the Akt signaling pathway

28 September 2017

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Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

28 September 2017

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RUNX family: Regulation and diversification of roles through interacting proteins

28 September 2017

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Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

28 September 2017

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Runx2 Protein Stabilizes Hypoxia-inducible Factor-1α through Competition with von Hippel-Lindau Protein (pVHL) and Stimulates Angiogenesis in Growth Plate Hypertrophic Chondrocytes

28 September 2017

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28 September 2017

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Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility

28 September 2017

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28 September 2017

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Glucose‐activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype

28 September 2017

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Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression

28 September 2017

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28 September 2017

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FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion

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28 September 2017

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Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis

28 September 2017

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28 September 2017

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The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells

28 September 2017

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Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions

28 September 2017

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28 September 2017

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28 September 2017

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Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells

28 September 2017

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Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.

28 September 2017

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28 September 2017

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Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway

28 September 2017

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Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

28 September 2017

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The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

28 September 2017

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CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12.

28 September 2017

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Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription.

28 September 2017

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Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

28 September 2017

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28 September 2017

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Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cells

28 September 2017

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Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein

28 September 2017

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Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

28 September 2017

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

28 September 2017

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Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas

28 September 2017

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PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells.

31 May 2018

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Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

31 May 2018

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Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation.

31 May 2018

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Crossref

https://api.crossref.org/works/10.1186/S12943-015-0404-3

Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform.

21 January 2018

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12 December 2020

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

1 reference

12 December 2020

Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients

1 reference

12 December 2020

Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo

1 reference

12 December 2020

10.1186/S12943-015-0404-3

Identifiers

DOI

1 reference

Dimensions Publication ID

1021938349

0 references

Fatcat ID

release_np77n4lyfjdmdjxoyt6sd7xuvu

0 references

1 reference

1 reference

PubMed publication ID

26204939

1 reference