Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models (Q26779458)

Universally sloppy parameter sensitivities in systems biology models

volume

4

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issue

2

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page(s)

69-79

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cites work

1 reference

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Investigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysis

7 April 2017

1 reference

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Emergent properties of networks of biological signaling pathways

7 April 2017

1 reference

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Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence

7 April 2017

1 reference

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What can we learn from global sensitivity analysis of biochemical systems?

7 April 2017

1 reference

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Computational systems biology

7 April 2017

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A systems pharmacology perspective on the clinical development of Fatty Acid amide hydrolase inhibitors for pain

7 April 2017

1 reference

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Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology

28 September 2017

1 reference

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A review of techniques for parameter sensitivity analysis of environmental models

28 September 2017

1 reference

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NIH Support for the Emergence of Quantitative and Systems Pharmacology

28 September 2017

1 reference

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Predicting nonlinear changes in bone mineral density over time using a multiscale systems pharmacology model

28 September 2017

1 reference

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Moving from basic toward systems pharmacodynamic models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Parameter uncertainty in biochemical models described by ordinary differential equations.

28 September 2017

1 reference

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Systems approaches in risk assessment.

28 September 2017

1 reference

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Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.

28 September 2017

1 reference

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Merging systems biology with pharmacodynamics

28 September 2017

1 reference

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Sensitivity analysis approaches applied to systems biology models.

28 September 2017

1 reference

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Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network

28 September 2017

1 reference

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Coping with time scales in disease systems analysis: application to bone remodeling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Diseases as network perturbations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Sensitivity analysis: from model parameters to system behaviour

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

A new strategy for assessing sensitivities in biochemical models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

A methodology for performing global uncertainty and sensitivity analysis in systems biology.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Sensitivity analysis of intracellular signaling pathway kinetics predicts targets for stem cell fate control

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Dynamic modelling and analysis of biochemical networks: mechanism-based models and model-based experiments.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Uncertainty analysis in pharmacokinetics and pharmacodynamics: application to naratriptan

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Identification and review of sensitivity analysis methods

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Modeling and stimulation for clinical trial design involving a categorical response: a phase II case study with naratriptan

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Feedback control of intercellular signalling in development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Evaluating systems pharmacology models is different from evaluating standard pharmacokinetic-pharmacodynamic models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

A General Network Pharmacodynamic Model-Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway

31 May 2018

1 reference

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Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

Sensitivity analysis of a two-dimensional probabilistic risk assessment model using analysis of variance.

31 May 2018

1 reference

In silico identification of the key components and steps in IFN-gamma induced JAK-STAT signaling pathway

21 January 2018

1 reference

Evaluation and recommendation of sensitivity analysis methods for application to Stochastic Human Exposure and Dose Simulation models

21 January 2018

1 reference

A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients

21 January 2018

1 reference

Dynamics of HIV infection of CD4 T cells.

21 January 2018

1 reference

A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling

21 January 2018

1 reference

Stochastic modelling for quantitative description of heterogeneous biological systems

21 January 2018

1 reference

Comment on: A validated mathematical model of cell-mediated immune response to tumor growth

21 January 2018

1 reference

A validated mathematical model of cell-mediated immune response to tumor growth.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006244

28 November 2018

Identifiers

DOI

10.1002/PSP4.6

1 reference

release_qypxzg4vjzhf5gt3o5hmlapyg4

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

27548289

1 reference