The Importance of Thrombin in Cerebral Injury and Disease (Q26772131)

2

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Sven Danckwardt

3

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Oliver Kempski

4

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Beat Alessandri

International Journal of Molecular Sciences

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language of work or name

English

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publication date

11 January 2016

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19 March 2019

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25 April 2019

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28 September 2019

27 November 2019

28 April 2021

29 April 2021

28 October 2022

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19 March 2019

22 March 2019

25 April 2019

17 June 2019

12 September 2019

28 September 2019

27 November 2019

28 April 2021

29 April 2021

28 October 2022

17

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issue

1

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page(s)

84

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copyright license

Creative Commons Attribution

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19 March 2019

22 March 2019

25 April 2019

17 June 2019

12 September 2019

28 September 2019

27 November 2019

28 April 2021

29 April 2021

28 October 2022

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on focus list of Wikimedia project

ScienceSource

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cites work

Acquired immunodeficiency syndrome and the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

PARticipation in inflammation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Protease-activated receptor 3 is a second thrombin receptor in humans

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Molecular cloning of a potential proteinase activated receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

GpIbα Interacts Exclusively with Exosite II of Thrombin

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Coagulation factor Xa activates thrombin in ischemic neural tissue

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin-receptor activation and thrombin-induced brain tolerance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The coagulation cascade: initiation, maintenance, and regulation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Oxidative stress in Parkinson's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin signalling and protease-activated receptors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Early detection of thrombin activity in neuroinflammatory disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Endogenous protease nexin-1 protects against cerebral ischemia.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

HIV stroke risk: evidence and implications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Review: activation patterns of microglia and their identification in the human brain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Enhanced effector function of CD8( ) T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated receptor 1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Donepezil combined with natural hirudin improves the clinical symptoms of patients with mild-to-moderate Alzheimer's disease: a 20-week open-label pilot study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

HIV infection is associated with decreased thrombin generation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Combined argatroban and anti‐oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Induction of apoptosis by thrombin in the cultured neurons of dorsal motor nucleus of the vagus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Dabigatran: An Oral Novel Potent Reversible Nonpeptide Inhibitor of Thrombin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Intracerebral haemorrhage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The effect of thrombin on a 6-hydroxydopamine model of Parkinson's disease depends on timing.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Ca2 -permeable AMPA receptors in synaptic plasticity and neuronal death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Brain injury after intracerebral hemorrhage: the role of thrombin and iron.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Calcium-permeable AMPA channels in neurodegenerative disease and ischemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Role of platelets and serine proteinases in coupling of blood coagulation and inflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin activates envelope glycoproteins of HIV type 1 and enhances fusion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Protease-activated receptors: contribution to physiology and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin signaling in the brain: the role of protease-activated receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The role of thrombin and thrombin receptors in ischemic, hemorrhagic and traumatic brain injury: deleterious or protective?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Hirudin as alternative anticoagulant--a historical review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin generation and its inhibition: a review of the scientific basis and mechanism of action of anticoagulant therapies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Role of thrombin in CNS damage associated with intracerebral haemorrhage: opportunity for pharmacological intervention?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin receptor signaling to cytoskeleton requires Hsp90.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Proteinase-activated receptors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Serine proteases and brain damage - is there a link?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Expression of factor X in both the rat brain and cells of the central nervous system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Etiology and pathogenesis of Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Cellular consequences of thrombin-receptor activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Protease-activated receptors start a family

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The clot thickens: clues provided by thrombin structure.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Molecular mechanisms of thrombin signaling.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Proteolytic regulation of neurite outgrowth from neuroblastoma cells by thrombin and protease nexin-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Role of the clotting system in the pathogenesis of neuroimmunologic disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Argatroban tPA stroke study: study design and results in the first treated cohort

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Co-existence of two types of [Ca2 ]i-inducing protease-activated receptors (PAR-1 and PAR-2) in rat astrocytes and C6 glioma cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Mechanisms of edema formation after intracerebral hemorrhage: effects of thrombin on cerebral blood flow, blood-brain barrier permeability, and cell survival in a rat model

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Edema from intracerebral hemorrhage: the role of thrombin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Activation of coagulation after administration of tumor necrosis factor to normal subjects

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Prothrombin mRNA is expressed by cells of the nervous system

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Prenatal and postnatal expression of mRNA coding for rat prothrombin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Production of thrombin and antithrombin III by brain and astroglial cell cultures.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin accumulation in brains of patients with Alzheimer's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

The prolonged presence of glia-derived nexin, an endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Novel expression and localization of active thrombomodulin on the surface of mouse brain astrocytes

31 May 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Plasminogen activator inhibitor-1 induction after experimental intracerebral hemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Protease-activated receptor-1 induces generation of new microglia in the dentate gyrus of traumatised hippocampal slice cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Participation of protease-activated receptor-1 in thrombin-induced microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin is a regulator of astrocytic endothelin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin-activated microglia contribute to death of dopaminergic neurons in rat mesencephalic cultures: dual roles of mitogen-activated protein kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin induces nigral dopaminergic neurodegeneration in vivo by altering expression of death-related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin induces neurodegeneration and microglial activation in the cortex in vivo and in vitro: proteolytic and non-proteolytic actions

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin preconditioning provides protection in a 6-hydroxydopamine Parkinson's disease model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Protease-activated receptor-1 mediates protection elicited by thrombin preconditioning in a rat 6-hydroxydopamine model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

The intrastriatal injection of thrombin in rat induced a retrograde apoptotic degeneration of nigral dopaminergic neurons through synaptic elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Trimethyltin-induced differential expression of PAR subtypes in reactive astrocytes of the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Protease activated receptor-1 antagonist ameliorates the clinical symptoms of experimental autoimmune encephalomyelitis via inhibiting breakdown of blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Transient focal ischemia in rat brain differentially regulates mRNA expression of protease-activated receptors 1 to 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Attenuation of thrombin-induced brain edema by cerebral thrombin preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Preconditioning with thrombin can be protective or worsen damage after endothelin-1-induced focal ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Protease-activated receptor-1 protects rat astrocytes from apoptotic cell death via JNK-mediated release of the chemokine GRO/CINC-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Holo-transferrin and thrombin can interact to cause brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Thrombin potently enhances swelling-sensitive glutamate efflux from cultured astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Modulation of hippocampal neuron survival by thrombin and factor Xa.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Chronic thrombin exposure results in an increase in apolipoprotein-E levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3390/IJMS17010084

Up-regulation of brain ceruloplasmin in thrombin preconditioning

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Prothrombin overexpressed in post-natal neurones requires blood factors for activation in the mouse brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin preconditioning, heat shock proteins and thrombin-induced brain edema.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4730327

Thrombin exacerbates brain edema in focal cerebral ischemia

28 November 2018

1 reference

12 December 2020

Overexpression of interleukin-1 receptor antagonist reduces brain edema induced by intracerebral hemorrhage and thrombin

1 reference

12 December 2020

Activation of protease-activated receptors in astrocytes evokes a novel neuroprotective pathway through release of chemokines of the growth-regulated oncogene/cytokine-induced neutrophil chemoattractant family

1 reference

12 December 2020

Potentiation of NMDA receptor function by the serine protease thrombin

1 reference

12 December 2020

Intracerebral hirudin injection attenuates ischemic damage and neurologic deficits without altering local cerebral blood flow

1 reference

12 December 2020

Challenging the anticoagulant paradigm?

1 reference

12 December 2020

Proteinase-Activated Receptor-2 Induction by Neuroinflammation Prevents Neuronal Death during HIV Infection

1 reference

12 December 2020

Variable and multiple expression of Protease Nexin-1 during mouse organogenesis and nervous system development

1 reference

12 December 2020

Thrombin causes cell spreading and redistribution of beta-amyloid immunoreactivity in cultured hippocampal neurons

1 reference

12 December 2020

Protease nexin-1 and thrombin: injury-related processes in the brain

1 reference

12 December 2020

The effects of thrombin preconditioning on focal cerebral ischemia in rats

1 reference

12 December 2020

Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: localization, expression and participation in neurodegenerative diseases

1 reference

12 December 2020

Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B

1 reference

12 December 2020

Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra

1 reference

12 December 2020

Inactivation of Thrombin by Antithrombin Is Accompanied by Inactivation of Regulatory Exosite I

1 reference

12 December 2020

Secondary parkinsonism following midbrain hemorrhage

1 reference

12 December 2020

Immunohistochemical studies of human tissues with antibody to factor Xa

1 reference

12 December 2020

Plasma thrombin-antithrombin III complex is associated with the severity of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Thrombin-induced activation of cultured rodent microglia

1 reference

12 December 2020

Transduction mechanisms involved in thrombin receptor-induced nerve growth factor secretion and cell division in primary cultures of astrocytes

1 reference

12 December 2020

Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions. An immunohistochemical study

1 reference

12 December 2020